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Wiley A. Schell
Researcher at Duke University
Publications - 93
Citations - 6326
Wiley A. Schell is an academic researcher from Duke University. The author has contributed to research in topics: Candida albicans & Cryptococcus neoformans. The author has an hindex of 41, co-authored 91 publications receiving 5826 citations. Previous affiliations of Wiley A. Schell include Research Triangle Park & Veterans Health Administration.
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Journal ArticleDOI
Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease
Leah E. Cowen,Sheena D. Singh,Julia R. Köhler,Cathy Collins,Aimee K. Zaas,Wiley A. Schell,Hamza Aziz,Eleftherios Mylonakis,John R. Perfect,Luke Whitesell,Susan Lindquist +10 more
TL;DR: Hsp90 provides a much-needed strategy for improving the treatment of fungal disease because it enhances the efficacy of existing antifungals, blocks the emergence of drug resistance, and exerts broad-spectrum activity against diverse fungal pathogens.
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Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin.
TL;DR: It is demonstrated that Hsp90 governs cellular circuitry required for resistance to the only new class of antifungals to reach the clinic in decades, the echinocandins, which inhibit biosynthesis of a critical component of the fungal cell wall.
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Multiplexed Real-Time Polymerase Chain Reaction on a Digital Microfluidic Platform
Zhishan Hua,Jeremy Rouse,Allen E. Eckhardt,Vijay Srinivasan,Vamsee K. Pamula,Wiley A. Schell,Jonathan L. Benton,Thomas G. Mitchell,Michael G. Pollack +8 more
TL;DR: A versatile digital microfluidic platform for multiplexed real-time polymerase chain reactions (PCR) that reliably detected diagnostic DNA levels of methicillin-resistant Staphylococcus aureus, Mycoplasma pneumoniae, and Candida albicans and was consistently repeatable across multiple PCR loops both within and between cartridges.
Journal ArticleDOI
PKC Signaling Regulates Drug Resistance of the Fungal Pathogen Candida albicans via Circuitry Comprised of Mkc1, Calcineurin, and Hsp90
Shantelle L. LaFayette,Cathy Collins,Aimee K. Zaas,Wiley A. Schell,Marisol Betancourt-Quiroz,A. A. Leslie Gunatilaka,John R. Perfect,Leah E. Cowen +7 more
TL;DR: A new role for PKC signaling in drug resistance, novel circuitry through which Hsp90 regulates drug resistance is established, and that targeting stress response signaling provides a promising strategy for treating life-threatening fungal infections are established.
Journal ArticleDOI
The New Fungal Opportunists Are Coming
John R. Perfect,Wiley A. Schell +1 more
TL;DR: This discussion addresses several issues of pathogenesis, epidemiology, diagnosis, and treatment with regard to these new opportunists, through a review of both general and specific concepts.