Christopher J. Frederickson

TL;DR: The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC, and the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'.

TL;DR: This chapter discusses separate pools of CNS zinc, which are, vesicular zinc, free zinc, and protein-bound zinc; the enzymatic zinc is, therefore, a stable pool, involved only in the specific function of the zinc-containing enzymes.

TL;DR: It is reported that the mossy-fibre neuropil and cells of origin (dentate granule cells) take up zinc preferentially, and that electrical stimulation selectively facilitates both uptake of exogenous zinc into mossY-f fibre neuro pil and release of previously incorporated 65Zn from the tissue.

TL;DR: The present review outlines the methods used to discover, define and describe zinc-containing neurons; the neuroarchitecture and synaptology of zinc- containing neural circuits; the physiology of regulated vesicular zinc release; the "life cycle" and molecular biology of vesicle zinc; the importance of synaptically released zinc in the normal and pathological processes of the cerebral cortex; and the role of specific and nonspecific stressors in the release of zinc.

TL;DR: A histochemical method for staining CNS zinc by the stoichiometric formation of zinc: quinoline fluorescent chelates is described, and data indicate that the fluorochrome can be used for quantitative estimates of CNS zinc pools as well as qualitative studies of localization.