Journal ArticleDOI
Stimulation-induced uptake and release of zinc in hippocampal slices.
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TLDR
It is reported that the mossy-fibre neuropil and cells of origin (dentate granule cells) take up zinc preferentially, and that electrical stimulation selectively facilitates both uptake of exogenous zinc into mossY-f fibre neuro pil and release of previously incorporated 65Zn from the tissue.Abstract:
The mossy-fibre axons of the hippocampus form a dense plexus, uniquely rich in chelatable zinc. Because the metal is apparently concentrated within the terminal bags of the axons, it has been hypothesized that the zinc is involved in mossy-fibre synaptic transmission. Although some electrophysiological findings have favoured the hypothesis, neither preferential uptake of zinc into the hippocampus nor depolarization-induced release of zinc from hippocampal tissue has previously been found. Using the hippocampal slice preparation, we now report that the mossy-fibre neuropil and cells of origin (dentate granule cells) take up zinc preferentially, and that electrical stimulation selectively facilitates both uptake of exogenous zinc into mossy-fibre neuropil and release of previously incorporated 65Zn from the tissue. The results suggest that the role of zinc in mossy-fibre axons is dynamically linked to neural signalling processes.read more
Citations
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Copper, iron and zinc in Alzheimer's disease senile plaques
TL;DR: Concentrations of copper (Cu), iron (Fe) and zinc (Zn) were measured in the rims and cores of senile plaques (SP) and in the neuropil of the amygdala of nine Alzheimer's disease patients and in that of five neurologically normal control subjects using micro particle-induced X-ray emission (micro-PIXE).
Journal ArticleDOI
Metals in Neurobiology: Probing Their Chemistry and Biology with Molecular Imaging
TL;DR: The brain is a singular organ of unique biological complexity that serves as the command center for cognitive and motor function and has requirements for the highest concentrations of metal ions in the body and the highest per-weight consumption of body oxygen.
Journal ArticleDOI
The neurobiology of zinc in health and disease
TL;DR: The use of zinc in medicinal skin cream was mentioned in Egyptian papyri from 2000 BC, and the number of biological functions, health implications and pharmacological targets that are emerging for zinc indicate that it might turn out to be 'the calcium of the twenty-first century'.
Journal ArticleDOI
Rapid induction of Alzheimer A beta amyloid formation by zinc.
Ashley I. Bush,Warren H. Pettingell,Gerd Multhaup,Marc d. Paradis,Jean-Paul Vonsattel,James F. Gusella,Konrad Beyreuther,Colin L. Masters,Rudolph E. Tanzi +8 more
TL;DR: A role for cerebral zinc metabolism in the neuropathogenesis of Alzheimer's disease is suggested, as concentrations of zinc above 300 nM rapidly destabilized human A beta 1-40 solutions, inducing tinctorial amyloid formation.
Journal ArticleDOI
The metallobiology of Alzheimer's disease.
TL;DR: Compounds that interdict metal-ion binding to Abeta dissolve brain deposits in vitro and one such compound, clioquinol, inhibits Abeta deposition in the Tg2576 mouse model for AD and could be useful clinically.
References
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Journal ArticleDOI
The Determination of Enzyme Dissociation Constants
Hans Lineweaver,Dean Burk +1 more
TL;DR: On the basis of the assumed theory the rate of the observed reaction is directly proportional to the concentration of the enzyme-substrate compound, where (E:l = (ES).
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Localization of transmitter candidates in the brain: the hippocampal formation as a model
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Electron microscopical localization of the zinc in hippocampal mossy fibre synapses by a modified sulfide silver procedure.
TL;DR: In this study, the sulfide silver method of Timm was modified, including the use of formaldehyde as a fixative, to give a tolerable degree of ultrastructural preservation.
Journal ArticleDOI
Cytoarchitectonic distribution of zinc in the hippocampus of man and the rat
TL;DR: Zinc was measured in whole hippocampus and in hippocampal sub-regions by stable-isotope dilution mass spectrometry and in both man and the rat, the most zinc was found in the hilar region, the least in the fimbria.
Journal ArticleDOI
An improved Timm sulphide silver method for light and electron microscopic localization of heavy metals in biological tissues.
Gorm Danscher,Jens Zimmer +1 more
TL;DR: Modifications of the Timm sulphide silver method for the demonstration of heavy metals are described and the staining of autolytic, postmortal human brain tissue is demonstrated.
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