C
Christopher J. Hetherington
Researcher at Harvard University
Publications - 32
Citations - 5443
Christopher J. Hetherington is an academic researcher from Harvard University. The author has contributed to research in topics: Transcription factor & Regulation of gene expression. The author has an hindex of 27, co-authored 32 publications receiving 5268 citations. Previous affiliations of Christopher J. Hetherington include Boston University & Beth Israel Deaconess Medical Center.
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Journal ArticleDOI
Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice
Dong-Er Zhang,Pu Zhang,Nai-dy Wang,Christopher J. Hetherington,Gretchen J. Darlington,Daniel G. Tenen +5 more
TL;DR: A model by which transcription factors can direct the differentiation of multipotential precursors through activation of expression of a specific growth factor receptor, allowing proliferation and differentiation in response to a specific extracellular signal is suggested.
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AML1-ETO expression is directly involved in the development of acute myeloid leukemia in the presence of additional mutations
Youzhong Yuan,Liming Zhou,Toshihiro Miyamoto,Hiromi Iwasaki,Nari Harakawa,Christopher J. Hetherington,Sebastien A. Burel,Eric Lagasse,Irving L. Weissman,Koichi Akashi,Dong-Er Zhang +10 more
TL;DR: Results provide direct evidence that AML1-ETO is critical for causing myeloid leukemia, but one or more additional mutations are required for leukemogenesis.
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The macrophage transcription factor PU.1 directs tissue-specific expression of the macrophage colony-stimulating factor receptor.
TL;DR: In this paper, the authors investigated whether PU.1 binds and activates the macrophage colony-stimulating factor (M-CSF) receptor promoter in a tissue-specific fashion from two distinct promoters in monocytes and the placenta.
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CCAAT enhancer-binding protein (C/EBP) and AML1 (CBF alpha2) synergistically activate the macrophage colony-stimulating factor receptor promoter.
Dong-Er Zhang,Christopher J. Hetherington,S. Meyers,K. L. Rhoades,Christopher J. Larson,Hui-Min Chen,Scott W. Hiebert,Daniel G. Tenen +7 more
TL;DR: It is demonstrated that C/EBP and AML1 are important factors for regulating a critical hematopoietic growth factor receptor, the M-CSF receptor, suggesting a mechanism of how the AML 1 fusion protein could contribute to acute myeloid leukemia.
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Embryonic lethality and impairment of haematopoiesis in mice heterozygous for an AML1-ETO fusion gene.
Donald A. Yergeau,Christopher J. Hetherington,Qing Wang,Pu Zhang,Arlene H. Sharpe,Michael Binder,Miguel Marin-Padilla,Daniel G. Tenen,Nancy A. Speck,Dong-Er Zhang +9 more
TL;DR: Mice heterozygous for an AML1–ETO allele (AML1—ETO/+) die in midgestation from haemorrhaging in the central nervous system and exhibit a severe block in fetal liver haematopoiesis, indicating that AML-ETO blocks normal AML 1 function.