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Christopher N. Davis
Researcher at ACADIA Pharmaceuticals Inc.
Publications - 3
Citations - 104
Christopher N. Davis is an academic researcher from ACADIA Pharmaceuticals Inc.. The author has contributed to research in topics: Receptor & Protease-activated receptor 2. The author has an hindex of 3, co-authored 3 publications receiving 100 citations.
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Journal ArticleDOI
Identification and Characterization of Novel Small-Molecule Protease-Activated Receptor 2 Agonists
Luis R. Gardell,Jian Nong Ma,Jimmi Gerner Seitzberg,Anne E. Knapp,Hans H. Schiffer,Ali Tabatabaei,Christopher N. Davis,Michelle Owens,Bryan Clemons,Kenneth K. Wong,Birgitte W. Lund,Norman Nash,Yan Gao,Jelveh Lameh,Kara R. Schmelzer,Roger Olsson,Ethan S. Burstein +16 more
TL;DR: The first small-molecule protease-activated receptor (PAR) 2 agonists, AC-55541 and AC-264613, represent novel small-Molecule PAR2 agonists that will be useful in probing the physiological functions of PAR2 receptors.
Journal ArticleDOI
AC-186, a Selective Nonsteroidal Estrogen Receptor β Agonist, Shows Gender Specific Neuroprotection in a Parkinson’s Disease Rat Model
Krista McFarland,Diana L. Price,Christopher N. Davis,Jian-Nong Ma,Douglas W. Bonhaus,Ethan S. Burstein,Roger Olsson,Roger Olsson +7 more
TL;DR: In male rats, 17β-estradiol, which activates ERβ and ERα with equal potency, did not show the same neuroprotective benefits as AC-186, so in addition to a beneficial safety profile for use in both males and females, a selective ERβ agonist has a differentiated pharmacological profile compared to 17 β-ESTradiol in males.
Journal ArticleDOI
Differential regulation of muscarinic M1 receptors by orthosteric and allosteric ligands
Christopher N. Davis,Stefania Risso Bradley,Hans H. Schiffer,Mikael Friberg,Kristian Norup Koch,Bo-Ragnar Tolf,Douglas W. Bonhaus,Jelveh Lameh +7 more
TL;DR: Allosteric agonists differ from orthosteric ligands and among each other in their ability to induce different regulatory pathways are ligand specific, indicating that signaling and regulatory pathways induced by different allostericligands areligand specific.