J
Jian Nong Ma
Researcher at ACADIA Pharmaceuticals Inc.
Publications - 10
Citations - 313
Jian Nong Ma is an academic researcher from ACADIA Pharmaceuticals Inc.. The author has contributed to research in topics: Agonist & Calcium-sensing receptor. The author has an hindex of 9, co-authored 10 publications receiving 291 citations.
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Journal ArticleDOI
Discovery of the first nonpeptide agonist of the GPR14/Urotensin-II receptor: 3-(4-Chlorophenyl)-3-(2-(dimethylamino)ethyl)isochroman-1-one (AC-7954)
Glenn Croston,Roger Olsson,Erika A. Currier,Ethan S. Burstein,David M. Weiner,Norman Nash,Daniel L. Severance,Stig Allenmark,Linda Thunberg,Jian Nong Ma,Nina Mohell,Brian F. O'Dowd,Mark R. Brann,Mark R. Brann,Uli Hacksell +14 more
TL;DR: Testing of the enantiopure (+)- and (-)- 1 revealed that the UII receptor activity of racemic 1 resides primarily in (+)-1.
Journal ArticleDOI
Identification and Characterization of Novel Small-Molecule Protease-Activated Receptor 2 Agonists
Luis R. Gardell,Jian Nong Ma,Jimmi Gerner Seitzberg,Anne E. Knapp,Hans H. Schiffer,Ali Tabatabaei,Christopher N. Davis,Michelle Owens,Bryan Clemons,Kenneth K. Wong,Birgitte W. Lund,Norman Nash,Yan Gao,Jelveh Lameh,Kara R. Schmelzer,Roger Olsson,Ethan S. Burstein +16 more
TL;DR: The first small-molecule protease-activated receptor (PAR) 2 agonists, AC-55541 and AC-264613, represent novel small-Molecule PAR2 agonists that will be useful in probing the physiological functions of PAR2 receptors.
Journal ArticleDOI
Characterization of Highly Efficacious Allosteric Agonists of the Human Calcium-Sensing Receptor
Jian Nong Ma,Michelle Owens,Magnus Gustafsson,Jacob Jensen,Ali Tabatabaei,Kara R. Schmelzer,Roger Olsson,Ethan S. Burstein +7 more
TL;DR: These highly efficacious CaSR allosteric agonists represent leads for developing therapeutic agents with potential advantages over existing therapies and compared their pharmacology to phenylalkylamine calcimimetics.
Journal ArticleDOI
Discovery of potent and selective small-molecule PAR-2 agonists.
Jimmi Gerner Seitzberg,Anne E. Knapp,Birgitte W. Lund,Sine Mandrup Bertozzi,Erika A. Currier,Jian Nong Ma,Vladimir Sherbukhin,Ethan S. Burstein,Roger Olsson +8 more
TL;DR: The discovery and characterization of two structurally different, potent, selective, and metabolically stable small-molecule PAR-2 agonists are presented, which may be useful as pharmacological tools for elucidating the complex physiological role of thePAR-2 receptors as well as for the development of PAR- 2 antagonists.
Journal ArticleDOI
Synthesis and evaluation of dibenzothiazepines: a novel class of selective cannabinoid-1 receptor inverse agonists.
Hanna Pettersson,Anne Bulow,Fredrik Ek,Jacob Jensen,Lars Korsgaard Ottesen,Alma Fejzic,Jian Nong Ma,Andria L. Del Tredici,Erika A. Currier,Luis R. Gardell,Ali Tabatabaei,Darren Craig,Krista McFarland,Thomas R. Ott,Fabrice Piu,Ethan S. Burstein,Roger Olsson +16 more
TL;DR: A novel class of CB1 inverse agonists was discovered and a lead compound 11-(4-chlorophenyl)dibenzo[b,f][1,4]thiazepine-8-carboxylic acid butylamide (12e) which showed excellent in vivo activity in pharmacodynamic models related to CB1 receptor activity was discovered.