C
Christopher P. Leamon
Researcher at Endocyte
Publications - 158
Citations - 9651
Christopher P. Leamon is an academic researcher from Endocyte. The author has contributed to research in topics: Folate receptor & Cancer. The author has an hindex of 49, co-authored 155 publications receiving 9125 citations. Previous affiliations of Christopher P. Leamon include Isis Pharmaceuticals & Purdue University.
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Journal ArticleDOI
Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
Nikki Parker,Mary Jo Turk,Elaine Westrick,Jeffrey D. Lewis,Philip S. Low,Philip S. Low,Christopher P. Leamon +6 more
TL;DR: Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics.
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Delivery of macromolecules into living cells: a method that exploits folate receptor endocytosis.
TL;DR: F folate is an essential vitamin required in substantial quantities by virtually all cells, and the natural endocytosis pathway for the vitamin folate can be exploited to nondestructively introduce macromolecules into cultured cells if the macromolescule is first covalently linked to folate.
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Folate-targeted chemotherapy
TL;DR: This review will outline the manner in which folate-drug conjugates are screened preclinically, it will summarize published activity data of various conjugate, and it will highlight some newly emerging animal data from novel compounds that are currently under preclinical investigation.
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Folate-mediated targeting: from diagnostics to drug and gene delivery.
TL;DR: F folate-mediated drug delivery is summarized and those techniques undergoing active preclinical or clinical investigation are highlighted.
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The folate receptor as a rational therapeutic target for personalized cancer treatment
TL;DR: Targeted therapies combined with a reliable companion diagnostic test represent a novel approach toward efficient personalized medicine for malignant and nonmalignant disorders and forms a realistic basis for the rational design and implementation of novel FR-targeted drugs for the treatment of cancer and inflammatory disorders.