Journal•ISSN: 1368-7646
Drug Resistance Updates
Elsevier BV
About: Drug Resistance Updates is an academic journal published by Elsevier BV. The journal publishes majorly in the area(s): Cancer & Drug resistance. It has an ISSN identifier of 1368-7646. Over the lifetime, 691 publications have been published receiving 61031 citations.
Topics: Cancer, Drug resistance, Medicine, Biology, Cancer cell
Papers published on a yearly basis
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TL;DR: ROS stress in cancer cells is reviewed, its underlying mechanisms and relationship with mitochondrial malfunction and alteration in drug sensitivity are reviewed, and new therapeutic strategies that take advantage of increased ROS in cancer Cells to enhance therapeutic activity and selectivity are suggested.
1,823 citations
TL;DR: The successful development of new aminoglycosides refractory to as many as possible modifying enzymes would extend the useful life of existing antibiotics that have proven effective in the treatment of infections.
965 citations
TL;DR: This review will provide an update on the clinical progress of various agents that target the PI3K/Akt/mTOR pathway and discuss strategies to combine these pathway inhibitors with conventional chemotherapy, radiotherapy, as well as newer targeted agents.
760 citations
TL;DR: The senescent phenotype distinguishes tumor cells that survived drug exposure but lost the ability to form colonies from those that recover and proliferate after treatment, and should assist in improving the efficacy and decreasing side effects of cancer therapy.
732 citations
TL;DR: Methods to overcome the blood-brain tumor barrier barrier (BBTB) are provided, including osmotic blood- brain barrier disruption (BBBD), bradykinin receptor-mediated BBTB opening, inhibition of multidrug efflux transporters, receptor- mediated transport systems and physiological circumvention of the BBTB.
655 citations