P
Philip S. Low
Researcher at Purdue University
Publications - 608
Citations - 44158
Philip S. Low is an academic researcher from Purdue University. The author has contributed to research in topics: Folate receptor & Band 3. The author has an hindex of 104, co-authored 577 publications receiving 40795 citations. Previous affiliations of Philip S. Low include National Institutes of Health & University of Turin.
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Intraoperative tumor-specific fluorescence imaging in ovarian cancer by folate receptor-α targeting: first in-human results
Gooitzen M. van Dam,George Themelis,Lucia M. A. Crane,Niels J. Harlaar,Niels J. Harlaar,Rick G. Pleijhuis,W. Kelder,Athanasios Sarantopoulos,Johannes S. de Jong,Henriette J. G. Arts,Ate G.J. van der Zee,Joost Bart,Philip S. Low,Vasilis Ntziachristos +13 more
TL;DR: In patients with ovarian cancer, intraoperative tumor-specific fluorescence imaging with an FR-α–targeted fluorescent agent showcased the potential applications in patients with Ovarian cancer for improved intraoperative staging and more radical cytoreductive surgery.
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Folate receptor expression in carcinomas and normal tissues determined by a quantitative radioligand binding assay
Nikki Parker,Mary Jo Turk,Elaine Westrick,Jeffrey D. Lewis,Philip S. Low,Philip S. Low,Christopher P. Leamon +6 more
TL;DR: Overall, this new methodology is reliable for determining functional FR expression levels in tissues, and it could possibly be a useful clinical test to determine patient candidacy for FR-targeted therapeutics.
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Discovery and Development of Folic-Acid-Based Receptor Targeting for Imaging and Therapy of Cancer and Inflammatory Diseases
TL;DR: The quest for the ideal targeted therapeutic agent was described, which began with a search for ligands that would bind selectively to pathologic cells, displaying no affinity for healthy cells, and held great promise for increasing the potency while reducing toxicity of many cancer therapies.
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Folate-mediated delivery of macromolecular anticancer therapeutic agents
Yingjuan Lu,Philip S. Low +1 more
TL;DR: This review presents a brief mechanistic background of folate-targeted macromolecular therapeutics and then summarizes the successes and failures observed with each major application of the technology.
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In vitro and in vivo two-photon luminescence imaging of single gold nanorods
Haifeng Wang,Terry B. Huff,Daniel A. Zweifel,Wei He,Philip S. Low,Alexander Wei,Ji-Xin Cheng +6 more
TL;DR: Gold nanorods excited at 830 nm on a far-field laser-scanning microscope produced strong two-photon luminescence (TPL) intensities, with a cos(4) dependence on the incident polarization.