C
Christopher R DiPalma
Researcher at Amgen
Publications - 2
Citations - 334
Christopher R DiPalma is an academic researcher from Amgen. The author has contributed to research in topics: Pregnane X receptor & Thermogenesis. The author has an hindex of 2, co-authored 2 publications receiving 321 citations.
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Journal ArticleDOI
Impaired transport of leptin across the blood-brain barrier in obesity.
TL;DR: It is shown that the transport rate of leptin across the blood-brain barrier is reduced about 2/3 in 12-month-old obese CD-1 mice, suggesting a new model for obesity in which a defect in the BBB transport of leptin into the CNS underlies the insensitivity to leptin and leads to obesity.
Journal ArticleDOI
A novel statistical algorithm for gene expression analysis helps differentiate pregnane X receptor-dependent and independent mechanisms of toxicity.
M. Ann Mongan,Robert T. Dunn,Steven Vonderfecht,Nancy E. Everds,Guang Chen,Cheng Su,Marnie Higgins-Garn,Yuan Chen,Cynthia A. Afshari,Toni Williamson,Linda L. Carlock,Christopher R DiPalma,Suzanne C. Moss,Jeanine L. Bussiere,Charles W. Qualls,Yudong D. He,Hisham K. Hamadeh +16 more
TL;DR: A novel non-parametric algorithm that requires minimal assumptions about the data distribution is presented that captures group effect without being too sensitive to anomalies as it allows tolerance for potential non-responders in the treatment group and outliers in the control group.