Journal ArticleDOI
Impaired transport of leptin across the blood-brain barrier in obesity.
TLDR
It is shown that the transport rate of leptin across the blood-brain barrier is reduced about 2/3 in 12-month-old obese CD-1 mice, suggesting a new model for obesity in which a defect in the BBB transport of leptin into the CNS underlies the insensitivity to leptin and leads to obesity.About:
This article is published in Peptides.The article was published on 1999-11-01. It has received 325 citations till now. The article focuses on the topics: Leptin & Thermogenesis.read more
Citations
More filters
Journal ArticleDOI
Adipose Tissue as an Endocrine Organ
Rexford S. Ahima,Jeffery S Flier +1 more
TL;DR: The discovery of leptin in the mid-1990s has focused attention on the role of proteins secreted by adipose tissue, which is also involved in the regulation of neuroendocrine and immune function and the metabolic and cardiovascular complications associated with obesity.
Journal ArticleDOI
Leptin regulation of neuroendocrine systems.
TL;DR: It is shown that leptin's effects on energy balance and the neuroendocrine axis are mediated by projections to other hypothalamic nuclei, e.g., paraventricular, lateral, and perifornical areas, as well as other sites in the brainstem, spinal cord, and cortical and subcortical regions.
Journal ArticleDOI
Region-Specific Leptin Resistance within the Hypothalamus of Diet-Induced Obese Mice
TL;DR: The study suggests that the ARC is selectively leptin resistant in DIO mice and that this may be caused by elevated suppressor of cytokine signaling 3 in this hypothalamic nucleus.
Journal ArticleDOI
From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery
TL;DR: Some of the most important areas that have recently redefined the BBB are reviewed and how they can be applied to the development of CNS therapeutics are discussed.
Journal ArticleDOI
Extent and Direction of Ghrelin Transport Across the Blood-Brain Barrier Is Determined by Its Unique Primary Structure
TL;DR: It is shown that ghrelin transport across the blood-brain barrier is a complex, highly regulated bidirectional process, defining a new role for the unique post-translational octanoylation.
References
More filters
Journal ArticleDOI
Positional cloning of the mouse obese gene and its human homologue
Yiying Zhang,Ricardo Proenca,Ricardo Proenca,Margherita Maffei,Marisa Barone,Marisa Barone,Lori Leopold,Lori Leopold,Jeffrey M. Friedman,Jeffrey M. Friedman +9 more
TL;DR: The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot.
Journal ArticleDOI
Serum Immunoreactive-Leptin Concentrations in Normal-Weight and Obese Humans
Robert V. Considine,Madhur K. Sinha,Mark L. Heiman,Aidas Kriauciunas,Thomas W. Stephens,Mark R. Nyce,Joanna P. Ohannesian,Cheryl C. Marco,Linda J. McKee,Thomas L. Bauer,Jose F. Caro +10 more
TL;DR: Serum leptin concentrations are correlated with the percentage of body fat, suggesting that most obese persons are insensitive to endogenous leptin production.
Journal ArticleDOI
Graphical Evaluation of Blood-to-Brain Transfer Constants from Multiple-Time Uptake Data:
TL;DR: A theoretical model of blood–brain exchange is developed and a procedure is derived that can be used for graphing multiple-time tissue uptake data and determining whether a unidirectional transfer process was dominant during part or all of the experimental period.
Journal ArticleDOI
Leptin enters the brain by a saturable system independent of insulin.
William A. Banks,Abba J. Kastin,Abba J. Kastin,Weitao Huang,Weitao Huang,Jonathan B. Jaspan,Jonathan B. Jaspan,Lawrence M. Maness,Lawrence M. Maness +8 more
TL;DR: Results show that leptin is transported intact from blood to brain by a saturable system and inhibited the influx of 125I-leptin in a dose-dependent manner whereas unlabeled tyrosine and insulin, which have saturable transport systems, were without effect.
Journal ArticleDOI
Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance
Jose F. Caro,Jerzy W. Kolaczynski,Mark R. Nyce,Joanna P. Ohannesian,Irina Opentanova,Warren H Goldman,Richard B. Lynn,Peili Zhang,Madhur K. Sinha,Robert V. Considine +9 more
TL;DR: The data suggest that leptin enters the brain by a saturable transport system, lower in obese individuals, and may provide a mechanism for leptin resistance.