Christopher R. Loose

TL;DR: Ponericin G1, an antimicrobial peptide known to be highly active against S. aureus, was incorporated into a hydrolytically degradable polyelectrolyte multilayer film, which provided the level of control over drug loading and release kinetics required in medically relevant applications including coatings for implant materials and bandages, while eliminating susceptibility to bacterial resistance.

TL;DR: The rational design of new antimicrobial peptides are reported that show limited homology to naturally occurring proteins but have strong bacteriostatic activity against several species of bacteria, including Staphylococcus aureus and Bacillus anthracis.

TL;DR: To prevent complications over the life span of a device without using active drugs, a catheter is modified with the nonleaching polymeric sulfobetaine (polySB), which coordinates water molecules to the catheter surface, which effectively reduced protein, mammalian cell, and microbial attachment in vitro and in vivo.

TL;DR: In this article, a method for preparing and resulting articles of manufacture comprising a substrate having a surface, a bulk beneath the surface, and a grafted polymer layer on the substrate surface, in combination, constituting a modified surface having a fibrinogen adsorption of less than about 125 ng/cm2.

TL;DR: In this article, the non-fouling, polymeric material can be grafted to a variety of functionalized substrate materials, particularly polymeric substrates and/or polymeric undercoatings immobilized on a substrate.