C
Christopher W. Wong
Researcher at Genome Institute of Singapore
Publications - 30
Citations - 1367
Christopher W. Wong is an academic researcher from Genome Institute of Singapore. The author has contributed to research in topics: Apoptosis & Virus. The author has an hindex of 16, co-authored 29 publications receiving 1273 citations. Previous affiliations of Christopher W. Wong include Agency for Science, Technology and Research & University of Pennsylvania.
Papers
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Journal Article
Apoptosis: an early event in metastatic inefficiency.
Christopher W. Wong,Andrea Lee,Lisa Shientag,Jun Yu,Yao Dong,Gary D. Kao,Abu B. Al-Mehdi,Eric J. Bernhard,Ruth J. Muschel +8 more
TL;DR: This work shows that apoptosis in vivo corresponds to decreased metastasis in vivo, which is an important determinant of metastatic inefficiency.
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Laboratory-acquired severe acute respiratory syndrome
Poh Lian Lim,Asok Kurup,Gowri Gopalakrishna,Kwai Peng Chan,Christopher W. Wong,Lee Ching Ng,Su Yun Se-Thoe,Lynette Oon,Xinlai Bai,Lawrence W. Stanton,Yijun Ruan,Lance D. Miller,Vinsensius B. Vega,Lyn James,Peng Lim Ooi,Chew Suok Kai,Sonja J. Olsen,Brenda Ang,Brenda Ang,Brenda Ang,Yee Sin Leo,Yee Sin Leo,Yee Sin Leo +22 more
TL;DR: A graduate student in microbiology in Singapore in whom fever and respiratory symptoms led to the diagnosis of infection with the severe acute respiratory syndrome (SARS) virus in September 2003 is described.
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Intravascular location of breast cancer cells after spontaneous metastasis to the lung.
Christopher W. Wong,Chun Song,Maggie M. Grimes,Weili Fu,Mark W. Dewhirst,Ruth J. Muschel,Abu-Bakr Al-Mehdi +6 more
TL;DR: A model for pulmonary metastasis in mice is supported in which tumor cells can attach to lung endothelium soon after arrival; 2) surviving tumor cells proliferate intravascularly in this model; and 3) extravasation of the tumor occurs when intrav vascular micrometastatic foci outgrow the vessels they are in.
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RCP is a human breast cancer–promoting gene with Ras-activating function
Jinqiu Zhang,Xuejing Liu,Arpita Datta,Kunde R Govindarajan,Wai Leong Tam,Jianyong Han,Joshy George,Christopher W. Wong,Kalpana Ramnarayanan,Tze Yoong Phua,Wan Yee Leong,Yang Sun Chan,Nallasivam Palanisamy,Edison T. Liu,Krishna Karuturi,Bing Lim,Lance D. Miller +16 more
TL;DR: Results indicate that RCP is a multifunctional gene frequently amplified in breast cancer that encodes a protein with Ras-activating function that has potential importance as a therapeutic target, and these studies provide new insight into the emerging role of the Rab family of small G proteins and their interacting partners in carcinogenesis.
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Tracking the Evolution of the SARS Coronavirus Using High-Throughput, High-Density Resequencing Arrays
Christopher W. Wong,Thomas J. Albert,Vinsensius B. Vega,Jason Norton,David J. Cutler,Todd Richmond,Lawrence W. Stanton,Edison T. Liu,Lance D. Miller +8 more
TL;DR: It is demonstrated that array-based resequencing-by-hybridization is a fast, reliable, and economical alternative to capillary sequencing for obtaining SARS-CoV genomic sequence on a population scale, making this an ideal platform for the global monitoring of SARS -CoV and other small-genome pathogens.