J
Jianyong Han
Researcher at China Agricultural University
Publications - 18
Citations - 1892
Jianyong Han is an academic researcher from China Agricultural University. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 9, co-authored 12 publications receiving 1790 citations. Previous affiliations of Jianyong Han include Agency for Science, Technology and Research & Genome Institute of Singapore.
Papers
More filters
Journal ArticleDOI
Reprogramming of fibroblasts into induced pluripotent stem cells with orphan nuclear receptor Esrrb
Bo Feng,Jianming Jiang,Jianming Jiang,Petra Kraus,Jia-Hui Ng,Jian-Chien Dominic Heng,Jian-Chien Dominic Heng,Yun-Shen Chan,Yun-Shen Chan,Lai-Ping Yaw,Weiwei Zhang,Weiwei Zhang,Yuin-Han Loh,Yuin-Han Loh,Jianyong Han,Vinsensius B. Vega,Valere Cacheux-Rataboul,Bing Lim,Bing Lim,Thomas Lufkin,Huck-Hui Ng,Huck-Hui Ng +21 more
TL;DR: This work shows that the orphan nuclear receptor Esrrb functions in conjunction with Oct4 and Sox2 to mediate reprogramming of mouse embryonic fibroblasts (MEFs) to iPS cells, and indicates that it is possible to reprogram MEFs without exogenous Klf transcription factors and link a nuclear receptor to somatic cell reprograming.
Journal ArticleDOI
The nuclear receptor Nr5a2 can replace Oct4 in the reprogramming of murine somatic cells to pluripotent cells.
Jian-Chien Dominic Heng,Bo Feng,Jianyong Han,Jianming Jiang,Petra Kraus,Jia-Hui Ng,Yuriy L. Orlov,Mikael Huss,Lin Yang,Thomas Lufkin,Thomas Lufkin,Bing Lim,Bing Lim,Huck-Hui Ng,Huck-Hui Ng +14 more
TL;DR: It is shown that the orphan nuclear receptor Nr5a2 (also known as Lrh-1) can replace Oct4 in the derivation of iPSCs from mouse somatic cells, and it can also enhance reprogramming efficiency.
Journal ArticleDOI
Tbx3 improves the germ-line competency of induced pluripotent stem cells
Jianyong Han,Ping Yuan,Henry Yang,Jinqiu Zhang,Boon Seng Soh,Pin Li,Siew Lan Lim,Suying Cao,Junliang Tay,Yuriy L. Orlov,Thomas Lufkin,Huck-Hui Ng,Wai Leong Tam,Bing Lim +13 more
TL;DR: iPS cells generated with OSK and Tbx3 (OSKT) are superior in both germ-cell contribution to the gonads and germ-line transmission frequency, and the need to rigorously characterize iPS cells beyond in vitro studies is highlighted.
Journal ArticleDOI
Eset partners with Oct4 to restrict extraembryonic trophoblast lineage potential in embryonic stem cells
Ping Yuan,Jianyong Han,Guoji Guo,Yuriy L. Orlov,Mikael Huss,Yuin-Han Loh,Lai-Ping Yaw,Paul Robson,Bing Lim,Huck-Hui Ng +9 more
TL;DR: The results suggest that Eset restricts the extraembryonic trophoblast lineage potential of pluripotent cells and links an epigenetic regulator to key cell fate decision through a pluripotency factor.
Journal ArticleDOI
T-cell factor 3 regulates embryonic stem cell pluripotency and self-renewal by the transcriptional control of multiple lineage pathways.
Wai Leong Tam,Chin Yan Lim,Jianyong Han,Jinqiu Zhang,Yen-Sin Ang,Huck-Hui Ng,Henry Yang,Bing Lim,Bing Lim +8 more
TL;DR: It is found that in mouse preimplantation development embryos, Tcf3 expression is coregulated with Oct4 and Nanog and becomes localized to the inner cell mass of the blastocyst, demonstrating an important role for TCF3 in modulating the appropriate level of gene transcription in ESCs and during embryonic development.