C
Chuanshu Huang
Researcher at New York University
Publications - 271
Citations - 14763
Chuanshu Huang is an academic researcher from New York University. The author has contributed to research in topics: Kinase & Signal transduction. The author has an hindex of 61, co-authored 263 publications receiving 12976 citations. Previous affiliations of Chuanshu Huang include Peking Union Medical College & Chinese Academy of Sciences.
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Journal ArticleDOI
Isorhapontigenin (ISO) inhibits stem cell-like properties and invasion of bladder cancer cell by attenuating CD44 expression
Yisi Luo,Zhongxian Tian,Xiaohui Hua,Maowen Huang,Jiheng Xu,Jingxia Li,Haishan Huang,Mitchell D. Cohen,Chuanshu Huang +8 more
TL;DR: The present study revealed that ISO could inhibit stem cell-like phenotypes and invasivity of human bladder cancer (BC) by specific attenuation of expression of CD44 but not SOX-2, at both the protein transcription and degradation levels.
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TNF-α Induction by Nickel Compounds is Specific Through ERKs/AP-1- Dependent Pathway in Human Bronchial Epithelial Cells
Jin Ding,Yi Huang,Bei-Fang Ning,Wenfeng Gong,Jingxia Li,Hongyang Wang,Chang-Yan Chen,Chuanshu Huang +7 more
TL;DR: Exposure of human bronchial epithelial cells to nickel compounds results in the induction of the inflammatory cytokine tumor necrosis factor-α (TNF-α) and transactivation of nuclear factor of activated T cells (NFAT), nuclear factor-κB (NF-κBs), and activator protein-1 (AP-1).
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JNK1, but not JNK2, is required for COX-2 induction by nickel compounds
Dongyun Zhang,Jingxia Li,Kangjian Wu,Weiming Ouyang,Jin Ding,Zheng-gang Liu,Max Costa,Chuanshu Huang +7 more
TL;DR: It is found that nickel exposure could induce cyclooxygenase-2 expression at transcriptional and protein levels in both human bronchoepithelial cells (Beas-2B) and murine embryonic fibroblasts (MEFs) and direct evidence for the specific involvement of the JNK1 signaling pathway in the COX-2 induction is provided.
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Activation of both nuclear factor of activated T cells and inhibitor of nuclear factor-κB kinase β-subunit-/nuclear factor-κB is critical for cyclooxygenase-2 induction by benzo[a]pyrene in human bronchial epithelial cells
Jin Ding,Kangjian Wu,Dongyun Zhang,Wenjing Luo,Jingxia Li,Weiming Ouyang,Lun Song,Chuanshu Huang +7 more
TL;DR: Exposure of Beas‐2B to B[a]P can upregulate COX‐2 expression by increasing its transcription, which requires activation of both the NFAT and NF‐κB signaling pathways.
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Epidermal Growth Factor Up-regulates the Transcription of Mouse Lon Homology ATP-Dependent Protease Through Extracellular Signal-Regulated Protein Kinase- and Phosphatidylinositol-3-Kinase-dependent Pathways
TL;DR: The role of Lon in tumor promotion warrants further study, as Mitochondria-localized Lon protease plays a critical role in the regulation of mitochondrial gene expression and genome integrity.