C
Chun-mei Li
Researcher at Huazhong Agricultural University
Publications - 73
Citations - 2107
Chun-mei Li is an academic researcher from Huazhong Agricultural University. The author has contributed to research in topics: Dimer & Medicine. The author has an hindex of 21, co-authored 67 publications receiving 1419 citations. Previous affiliations of Chun-mei Li include Chinese Ministry of Education.
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Spectroscopic investigations on the binding of persimmon tannin to phospholipase A2 from Chinese cobra (Naja naja atra)
TL;DR: In this article, the interaction between persimmon tannin (PT) and phospholipase A2 (PLA2) under physiological conditions was investigated by fluorescence quenching technique in combination with Fourier transform infrared (FT-IR) and circular dichroism (CD) spectra techniques.
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Simultaneous determination of the pharmacokinetics of A-type EGCG and ECG dimers in mice plasma and its metabolites by UPLC-QTOF-MS
TL;DR: It was found that two dimers were firstly experienced by quinone methide (QM) fission to form the EGCG and ECG analogue, and the phase II metabolites were generated subsequently and the main metabolites in plasma and urine were glucuronidation and sulphation derivatives.
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Persimmon tannin promoted macrophage reverse cholesterol transport through inhibiting ERK1/2 and activating PPARγ both in vitro and in vivo
TL;DR: In J774A.1 macrophage cells, persimmon tannin could inhibit cellular cholesterol accumulation and promote 22-NBD-cholesterol efflux through inhibiting the phosphorylation of ERK1/2 and up-regulating the protein levels of PPARγ.
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Persimmon Oligomeric Proanthocyanidins Exert Antibacterial Activity through Damaging the Cell Membrane and Disrupting the Energy Metabolism of Staphylococcus aureus
TL;DR: In this paper, the authors reported that high degrees of polymerization have seriously limited the applications of P-PCs in food processing, and they proposed a solution to this problem.
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Both non-covalent and covalent interactions were involved in the mechanism of detoxifying effects of persimmon tannin on Chinese cobra PLA2.
TL;DR: PT could bind with the key active residues of PLA2, such as lysine, histidine, tryptophan and tyrosine, restraining their activity and disturbing the structure ofPLA2, thus showing detoxifying effects on snake venom.