C
Chunfang Xia
Researcher at Siemens
Publications - 14
Citations - 1499
Chunfang Xia is an academic researcher from Siemens. The author has contributed to research in topics: In vivo & Terminal deoxynucleotidyl transferase. The author has an hindex of 9, co-authored 14 publications receiving 1377 citations.
Papers
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Journal ArticleDOI
Early Clinical PET Imaging Results with the Novel PHF-Tau Radioligand [F18]-T808
David Chien,A. Katrin Szardenings,Shadfar Bahri,Joseph C. Walsh,Fanrong Mu,Chunfang Xia,William R. Shankle,Alan J. Lerner,Min-Ying Su,Arkadij M. Elizarov,Hartmuth C. Kolb +10 more
TL;DR: First human brain images with [F18]-T808, a novel PHF-tau targeting PET imaging agent with different pharmacokinetic characteristics, are described, which may be favorable for imaging Alzheimer's disease and other tauopathies.
Journal ArticleDOI
[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease
Chunfang Xia,Janna Arteaga,Gang Chen,Umesh B. Gangadharmath,Luis F. Gomez,Dhanalakshmi Kasi,Chung Lam,Qianwa Liang,Changhui Liu,Vani P. Mocharla,Fanrong Mu,Anjana Sinha,Helen Su,A. Katrin Szardenings,Joseph C. Walsh,Eric Wang,Chul Yu,Wei Zhang,Tieming Zhao,Hartmuth C. Kolb +19 more
TL;DR: A highly selective positron emission tomography (PET) imaging agent targeting PHF‐tau in human Alzheimer's disease (AD) brains is developed.
Journal ArticleDOI
A Highly Selective and Specific PET Tracer for Imaging of Tau Pathologies
Wei Zhang,Janna Arteaga,Daniel Kurt Cashion,Gang Chen,Umesh B. Gangadharmath,Luis F. Gomez,Dhanalakshmi Kasi,Chung Lam,Qianwa Liang,Changhui Liu,Vani P. Mocharla,Fanrong Mu,Anjana Sinha,A. Katrin Szardenings,Eric Wang,Joseph C. Walsh,Chunfang Xia,Chul Yu,Tieming Zhao,Hartmuth C. Kolb +19 more
TL;DR: In vitro and preclinical in vivo studies suggest that [18F]-T808 possesses suitable properties and characteristics to be a specific and selective PET probe for imaging of paired helical filament tau in human brains.
Journal ArticleDOI
Evaluation of [ 18 F]-CP18 as a PET Imaging Tracer for Apoptosis
Helen Su,Gang Chen,Umesh B. Gangadharmath,Luis F. Gomez,Qianwa Liang,Fanrong Mu,Vani P. Mocharla,A. Katrin Szardenings,Joseph C. Walsh,Chunfang Xia,Chul Yu,Hartmuth C. Kolb +11 more
TL;DR: [18F]-CP18, a DEVD containing substrate-based compound as an imaging tracer for caspase-3 activity in apoptotic cells is identified and validated and further development of this tracer is supported for clinical PET applications.
Patent
Novel imaging agents for detecting neurological dysfunction
Hartmuth C. Kolb,Joseph C. Walsh,Qianwa Liang,Brian A. Duclos,Wei Zhang,Peter J. H. Scott,Kai Chen,Zhiyong Gao,Tieming Zhao,Vani P. Mocharla,Dhanalakshmi Kasi,Gang Chen,Eric Wang,Anjana Sinha,Chunfang Xia,Henry C. Padgett,Farhad Karimi +16 more
TL;DR: In this article, compounds and methods of diagnosing Alzheimer's disease or a predisposition thereto in a mammal are discussed. And the method comprising administering to the mammal a diagnostically effective amount of a radiolabeled compound, wherein the compound is selected from the group consisting of radiolabelled flavones, coumarins, carbazoles, quinolinones, chromenones, imidazoles and triazoles derivatives.