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Chung Y. Lu
Researcher at Northwestern University
Publications - 25
Citations - 997
Chung Y. Lu is an academic researcher from Northwestern University. The author has contributed to research in topics: Ornithine decarboxylase & Polyamine. The author has an hindex of 15, co-authored 25 publications receiving 989 citations. Previous affiliations of Chung Y. Lu include United States Department of Veterans Affairs.
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Journal ArticleDOI
Polyamines regulate calcium fluxes in a rapid plasma membrane response.
TL;DR: It is reported that testosterone evokes a rapid (<30 s), transient increase in ODC activity and a sustained increase in polyamines in kidney cortex, which forms the basis for a new theory of information flow in stimulus–response coupling in which the polyamines serve as messengers to generate a Ca2+ signal by increasing Ca2- influx and mobilizing intracellular calcium via a cation-exchange reaction.
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Blood brain barrier breakdown in brain edema following cold injury is mediated by microvascular polyamines
TL;DR: Results indicate that polyamine synthesis is obligatory for blood-brain barrier breakdown and alpha-Difluoromethylornithine may be useful in the treatment of vasogenic brain edema.
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Capillary NMDA receptors regulate blood-brain barrier function and breakdown.
TL;DR: It is suggested that NMDA receptors may couple capillary transport of nutrients to glutamate-mediated neuronal excitation, and when overestimated disrupt normal BBB function.
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Blood-brain barrier breakdown in cold-injured brain is linked to a biphasic stimulation of ornithine decarboxylase activity and polyamine synthesis: both are coordinately inhibited by verapamil, dexamethasone, and aspirin.
TL;DR: An early increase in ornithine decarboxylase (ODC) activity and polyamine levels in rat cerebral capillaries was previously implicated in the mediation of blood-brain barrier (BBB) breakdown in cold-injured brain this paper.
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Beta-adrenergic stimulation of Ca2+ fluxes, endocytosis, hexose transport, and amino acid transport in mouse kidney cortex is mediated by polyamine synthesis.
TL;DR: Polyamine synthesis in isoproterenol stimulation of Ca2+ fluxes and membrane transport processes is implicate in a model for signal transduction and stimulus-response coupling in which ornithine decarboxylase activation and polyamine synthesis play a pivotal role in regulating Ca2- fluxes.