C
Chunghee Cho
Researcher at Gwangju Institute of Science and Technology
Publications - 81
Citations - 3822
Chunghee Cho is an academic researcher from Gwangju Institute of Science and Technology. The author has contributed to research in topics: Gene & Sperm. The author has an hindex of 29, co-authored 79 publications receiving 3491 citations. Previous affiliations of Chunghee Cho include National Institutes of Health & University of California, Davis.
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Journal ArticleDOI
Fertilization Defects in Sperm from Mice Lacking Fertilin β
Chunghee Cho,Donna O. Bunch,Jean Emmanuel Faure,Eugenia H. Goulding,Edward M. Eddy,Paul Primakoff,Diana C. Myles +6 more
TL;DR: Fertilin, a member of the ADAM family, is found on the plasma membrane of mammalian sperm and could have a direct role in sperm-zona binding or oviduct migration; alternatively, the effects on these functions could result from the absence of fertilin activity during spermatogenesis.
Journal ArticleDOI
Haploinsufficiency of protamine-1 or -2 causes infertility in mice.
Chunghee Cho,William D. Willis,Eugenia H. Goulding,Haesook Jung-Ha,Young-Chul Choi,Norman B. Hecht,Edward M. Eddy +6 more
TL;DR: It is found that a decrease in the amount of either protamine disrupts nuclear formation, processing of protamine-2 and normal sperm function, and that haploinsufficiency caused by a mutation in one allele of Prm1 or Prm2 prevents genetic transmission of both mutant and wild-type alleles.
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Protamine 2 Deficiency Leads to Sperm DNA Damage and Embryo Death in Mice
Chunghee Cho,Haesook Jung-Ha,William D. Willis,Eugenia H. Goulding,Paula Stein,Zhe Xu,Richard M. Schultz,Norman B. Hecht,Edward M. Eddy +8 more
TL;DR: It is suggested that development fails because of damage to paternal DNA and that PRM2 is crucial for maintaining the integrity of sperm chromatin.
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Analysis of loss of adhesive function in sperm lacking cyritestin or fertilin beta.
TL;DR: Because the altered sperm protein expression must be responsible for the fertilization defects, the data suggest new models for the molecular basis of the affected steps in fertilization are suggested.
Journal ArticleDOI
Synthesis and structure-activity relationships of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities
Myoung Ju Moon,Sang Kook Lee,Jongwon Lee,Woo Keun Song,Si Wouk Kim,Jae Il Kim,Chunghee Cho,Soo Jeong Choi,Yong-Chul Kim +8 more
TL;DR: Among the indirubin derivatives tested in the growth inhibitions against several human cancer cell lines, 5-nitro, halide, and bulky group containing acylamino substituted analogs showed high anti-proliferative effects.