Chunxia Li

TL;DR: G-M DSCs may contribute to the IFN signature in SLE B cells through the NEAT1-BAFF axis, highlighting G-MDSCs as a potential therapeutic target to treat SLE.

TL;DR: It is concluded that treatment with zVAD alleviates LPS-induced endotoxic shock by inducing macrophage necroptosis and promoting MDSC-mediated inhibition of macrophages activation.

TL;DR: LA1-induced activation of CD11b negatively regulates L PS-induced pro-inflammatory response in macrophages and subsequently protects mice from endotoxin shock by partially blocking LPS-TLR4 interaction, providing a new insight into the role ofCD11b in the pathogenesis of inflammatory diseases.

TL;DR: The findings indicate that capsaicin pretreatment protects mice from Con A-induced hepatic damage and is partially involved in inhibiting hepatocyte apoptosis, oxidative stress, and inflammatory mediators as well as regulating activation and recruitment of intrahepatic leukocytes.

TL;DR: In vivo pharmacological inhibition of autophagy contributes to accumulation and immunosuppressive function of G-MDSCs by promoting the activation of STAT3 signaling, suggesting that Autophagy may play a critical role in regulating accumulation and activity of MDSCs.