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Chunxiang Zhang
Researcher at Rush University Medical Center
Publications - 56
Citations - 6913
Chunxiang Zhang is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Vascular smooth muscle & microRNA. The author has an hindex of 32, co-authored 56 publications receiving 6449 citations. Previous affiliations of Chunxiang Zhang include University of Tennessee Health Science Center & Rutgers University.
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Journal ArticleDOI
MicroRNA Expression Signature and Antisense-Mediated Depletion Reveal an Essential Role of MicroRNA in Vascular Neointimal Lesion Formation
Ruirui Ji,Yunhui Cheng,Junming Yue,Jian Yang,Xiaojun Liu,He Chen,David B. Dean,Chunxiang Zhang +7 more
TL;DR: The results suggest that miRNAs are novel regulatory RNAs for neointimal lesion formation and may be a new therapeutic target for proliferative vascular diseases such as atherosclerosis, postangioplasty restenosis, transplantation arteriopathy, and stroke.
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MicroRNA-145, a novel smooth muscle cell phenotypic marker and modulator, controls vascular neointimal lesion formation.
Yunhui Cheng,Xiaojun Liu,Jian Yang,Ying Lin,Da Zhong Xu,Qi Lu,Edwin A. Deitch,Yuqing Huo,Ellise Delphin,Chunxiang Zhang +9 more
TL;DR: It is demonstrated that miR-145 is a novel VSMC phenotypic marker and modulator that is able of controlling vascular neointimal lesion formation and this finding may have extensive implications for the diagnosis and therapy of a variety of proliferative vascular diseases.
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MicroRNAs Are Aberrantly Expressed in Hypertrophic Heart : Do They Play a Role in Cardiac Hypertrophy?
Yunhui Cheng,Ruirui Ji,Junming Yue,Jian Yang,Xiaojun Liu,He Chen,David B. Dean,Chunxiang Zhang +7 more
TL;DR: It is demonstrated that miRNAs are aberrantly expressed in hypertrophic mouse hearts, and modulating miR-21 expression via antisense-mediated depletion (knockdown) had a significant negative effect on cardiomyocyte hypertrophy.
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A Necessary Role of miR-221 and miR-222 in Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia
TL;DR: MiR-221 and miR-222 are novel regulators for VSMC proliferation and neointimal hyperplasia and may also represent promising therapeutic targets in proliferative vascular diseases.
Journal ArticleDOI
MicroRNA Expression Signature and the Role of MicroRNA-21 in the Early Phase of Acute Myocardial Infarction
Shimin Dong,Yunhui Cheng,Jian Yang,Jingyuan Li,Xiaojun Liu,Xiaobin Wang,Dong Wang,Thomas J. Krall,Ellise Delphin,Chunxiang Zhang +9 more
TL;DR: It is identified that miR-21 had a protective effect on ischemia-induced cell apoptosis that was associated with its target gene programmed cell death 4 and activator protein 1 pathway and was further confirmed in vivo by decreasedcell apoptosis in the border and infarcted areas of the infarCTed rat hearts after treatment with Ad-miR- 21.