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Chunxiang Zhang
Researcher at Rush University Medical Center
Publications - 56
Citations - 6913
Chunxiang Zhang is an academic researcher from Rush University Medical Center. The author has contributed to research in topics: Vascular smooth muscle & microRNA. The author has an hindex of 32, co-authored 56 publications receiving 6449 citations. Previous affiliations of Chunxiang Zhang include University of Tennessee Health Science Center & Rutgers University.
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Phospholipase D2-dependent Inhibition of the Nuclear Hormone Receptor PPARγ by Cyclic Phosphatidic Acid
Tamotsu Tsukahara,Ryoko Tsukahara,Yuko Fujiwara,Junming Yue,Yunhui Cheng,Huazhang Guo,Alyssa L. Bolen,Chunxiang Zhang,Louisa Balazs,Fabio Re,Guangwei Du,Michael A. Frohman,Daniel L. Baker,Abby L. Parrill,Ayako Uchiyama,Tetsuyuki Kobayashi,Kimiko Murakami-Murofushi,Gabor Tigyi +17 more
TL;DR: It is found that CPA is generated in mammalian cells in a stimulus-coupled manner by phospholipase D2 and binds to and inhibits the nuclear hormone receptor PPARgamma with nanomolar affinity and high specificity through stabilizing its interaction with the corepressor SMRT.
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An Endocrine Genetic Signal Between Blood Cells and Vascular Smooth Muscle Cells: Role of MicroRNA-223 in Smooth Muscle Function and Atherogenesis
Zhen Shan,Shanshan Qin,Wen Li,Weibin Wu,Jian Yang,Maoping Chu,Xiaokun Li,Yuqing Huo,Gary L. Schaer,Shenming Wang,Chunxiang Zhang +10 more
TL;DR: Blood cell-secreted miR-223 enters vascular cells and walls, and appears to play important roles in VSMC function and atherogenesis, and may provide a novel mechanism and new therapeutic target for atherosclerosis.
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Blockade of Nuclear Factor of Activated T Cells Activation Signaling Suppresses Balloon Injury-induced Neointima Formation in a Rat Carotid Artery Model
TL;DR: It is demonstrated for the first time that NFATs play a critical role in neointima formation via induction of expression of COX-2 through the inhibition of cyclosporine A and GFPVIVIT.
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MicroRNA-31 Regulated by the Extracellular Regulated Kinase Is Involved in Vascular Smooth Muscle Cell Growth via Large Tumor Suppressor Homolog 2
TL;DR: In this article, the expression of rat mature microRNA-31 (rno-miR-31) was determined in cultured vascular smooth muscle cells (VSMCs) and in rat carotid arteries.
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MicroRNA-145 in vascular smooth muscle cell biology: A new therapeutic target for vascular disease
TL;DR: In vitro and in vivo studies demonstrated that miR-145 is a critical modulator of VSMC phenotype and proliferation, and the potential therapeutic opportunities surrounding this miRNA in vascular disease are discussed.