C
Ciro Coletta
Researcher at University of Texas Medical Branch
Publications - 43
Citations - 4145
Ciro Coletta is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 25, co-authored 43 publications receiving 3434 citations. Previous affiliations of Ciro Coletta include University of Naples Federico II.
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Journal ArticleDOI
Tumor-derived hydrogen sulfide, produced by cystathionine-β-synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer
Csaba Szabó,Ciro Coletta,Celia Chao,Katalin Módis,Bartosz Szczesny,Andreas Papapetropoulos,Mark R. Hellmich +6 more
TL;DR: H2S produced from CBS serves to maintain colon cancer cellular bioenergetics, thereby supporting tumor growth and proliferation, and promote angiogenesis and vasorelaxation, consequently providing the tumor with blood and nutritients.
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Hydrogen sulfide and nitric oxide are mutually dependent in the regulation of angiogenesis and endothelium-dependent vasorelaxation
Ciro Coletta,Andreas Papapetropoulos,Andreas Papapetropoulos,Katalin Erdelyi,Gabor Olah,Katalin Módis,Panagiotis Panopoulos,Antonia Asimakopoulou,Domokos Gero,Iraida Sharina,Emil Martin,Csaba Szabó +11 more
TL;DR: The results of the current study show that H2S and NO are mutually required to elicit angiogenesis and vasodilatation, and the cooperative action of the two gasotransmitters on increasing and maintaining intracellular cGMP is essential for PKG activation and angiogenic and vasorelaxation.
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Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part I. Biochemical and physiological mechanisms
Csaba Szabó,Céline Ransy,Katalin Módis,Mireille Andriamihaja,Baptiste Murghes,Ciro Coletta,Gabor Olah,Kazunori Yanagi,Frédéric Bouillaud +8 more
TL;DR: The biochemical mechanisms underlying the stimulatory and inhibitory effects of H2S on mitochondrial function and cellular bioenergetics are overviewed and the implication of these processes for normal cellular physiology is discussed.
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Selectivity of commonly used pharmacological inhibitors for cystathionine β synthase (CBS) and cystathionine γ lyase (CSE)
Antonia Asimakopoulou,Panagiotis Panopoulos,Christos T. Chasapis,Ciro Coletta,Zongmin Zhou,Giuseppe Cirino,Athanassios Giannis,Csaba Szabó,Georgios A. Spyroulias,Andreas Papapetropoulos +9 more
TL;DR: This study examined the selectivity of commonly used pharmacological inhibitors of H2S biosynthesis towards CSE and CBS.
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Hydrogen sulfide replacement therapy protects the vascular endothelium in hyperglycemia by preserving mitochondrial function
Kunihiro Suzuki,Gabor Olah,Katalin Módis,Ciro Coletta,Gabriella Kulp,Domokos Gero,Petra Szoleczky,Tuanjie Chang,Zongmin Zhou,Lingyun Wu,Rui Wang,Andreas Papapetropoulos,Andreas Papapetropoulos,Csaba Szabó +13 more
TL;DR: Endogenously produced H2S protects against the development of hyperglycemia-induced endothelial dysfunction ex vivo, and it is hypothesized that, in hyperglycemic endothelial cells, mitochondrial ROS production and increased H1N1 catabolism form a positive feed-forward cycle.