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Claire L. Attwooll
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 4
Citations - 444
Claire L. Attwooll is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Fanconi anemia, complementation group C & BRIP1. The author has an hindex of 4, co-authored 4 publications receiving 426 citations.
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The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia.
Orna Levran,Claire L. Attwooll,Rashida Henry,Kelly Milton,Kornelia Neveling,Paula Río,Sat Dev Batish,Reinhard Kalb,Eunike Velleuer,Sandra Barral,Jurg Ott,John H.J. Petrini,Detlev Schindler,Helmut Hanenberg,Arleen D. Auerbach +14 more
TL;DR: Using genetic mapping, mutation identification and western-blot data, it is identified the defective protein in FA-J cells as BRIP1, a DNA helicase that is a binding partner of the breast cancer tumor suppressor BRCA1.
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The Mre11 Complex and the Response to Dysfunctional Telomeres
TL;DR: Data indicate that the Mre11 complex influences the cellular response to telomere dysfunction, reminiscent of its influence on the response to interstitial DNA breaks, and suggest that it may promote telomeric DNA end processing during DNA replication.
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Modeling disease in the mouse: Lessons from DNA damage response and cell cycle control genes
TL;DR: The strengths and weaknesses of mouse models, how they have advanced from gene deletions to truncations, point mutations, and conditional mouse models in which expression or loss of the gene of interest is controlled either temporally or spatially are discussed.
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