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Carrie A. Adelman
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 15
Citations - 1034
Carrie A. Adelman is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: DNA repair & Homologous recombination. The author has an hindex of 10, co-authored 13 publications receiving 938 citations. Previous affiliations of Carrie A. Adelman include Kettering University & London Research Institute.
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Journal ArticleDOI
Preventing nonhomologous end joining suppresses DNA repair defects of Fanconi anemia.
Adele Adamo,Spencer J. Collis,Spencer J. Collis,Carrie A. Adelman,Nicola Silva,Nicola Silva,Zuzana Horejsi,Jordan D. Ward,Enrique Martinez-Perez,Simon J. Boulton,Adriana La Volpe +10 more
TL;DR: It is proposed that a critical function of the FA pathway is to channel lesions into accurate, as opposed to error-prone, repair pathways, which is consistent with the interpretation that FA results from the promiscuous action of NHEJ during DNA repair.
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CK2 phospho-dependent binding of R2TP complex to TEL2 is essential for mTOR and SMG1 stability.
Zuzana Hořejší,Hiroyuki Takai,Carrie A. Adelman,Spencer J. Collis,Spencer J. Collis,Helen R. Flynn,Sarah L. Maslen,J. Mark Skehel,Titia de Lange,Simon J. Boulton +9 more
TL;DR: It is proposed that TEL2 acts as a scaffold to coordinate the activities of R2TP/prefoldin-like and HSP90 chaperone complexes during the assembly of the PIKKs.
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ZIP4H (TEX11) Deficiency in the Mouse Impairs Meiotic Double Strand Break Repair and the Regulation of Crossing Over
TL;DR: Results indicate that meiotic functions of Zip4 family members are conserved and support the view that the Mre11 complex and ZIP4H interact functionally during the execution of the meiotic program in mammals.
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The BMP/BMPR/Smad pathway directs expression of the erythroid-specific EKLF and GATA1 transcription factors during embryoid body differentiation in serum-free media
TL;DR: The data implicate the BMP/Smad induction system as being a crucial pathway to direct the onset of EKLF and GATA1 expression during hematopoietic differentiation and demonstrate that EB differentiation can be manipulated to study induction of specific genes that are expressed early within a lineage.
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HELQ promotes RAD51 paralogue-dependent repair to avert germ cell loss and tumorigenesis
Carrie A. Adelman,Rafal L. Lolo,Nicolai Juul Birkbak,Olga Murina,Kenichiro Matsuzaki,Zuzana Horejsi,Kalindi Parmar,Valerie Borel,J. Mark Skehel,J. Mark Skehel,Gordon Stamp,Alan D. D'Andrea,Alessandro A. Sartori,Charles Swanton,Simon J. Boulton +14 more
TL;DR: A critical role is revealed for HELQ in replication-coupled DNA repair, germ cell maintenance and tumour suppression in mammals and it is established that HELQ interacts directly with the RAD51 paralogue complex BCDX2 and functions in parallel to the Fanconi anaemia pathway to promote efficient homologous recombination at damaged replication forks.