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Claire Simons
Researcher at Cardiff University
Publications - 96
Citations - 2337
Claire Simons is an academic researcher from Cardiff University. The author has contributed to research in topics: Docking (molecular) & Retinoic acid. The author has an hindex of 23, co-authored 90 publications receiving 2018 citations. Previous affiliations of Claire Simons include King Faisal Specialist Hospital & Research Centre & UCL Institute of Child Health.
Papers
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Journal ArticleDOI
Use of hydrogen peroxide as a biocide: new consideration of its mechanisms of biocidal action
TL;DR: This review aims to combine past and novel evidence of interactions between hydrogen peroxide and the microbial cell and its components, while reflecting on alternative applications that make use of gaseous hydrogenperoxide.
Journal ArticleDOI
Mode of action of hydrogen peroxide and other oxidizing agents: differences between liquid and gas forms
Michelle Finnegan,Ezra Linley,Stephen Paul Denyer,Gerald E. Mcdonnell,Claire Simons,Jean-Yves Maillard +5 more
TL;DR: These results provide a comprehensive understanding of the differences in interactions between a number of oxidizing agents and macromolecules commonly found in microbial cells, particularly between liquid and gas peroxide.
Journal ArticleDOI
Synthetic methodologies for C-nucleosides
Qin-Pei Wu,Claire Simons +1 more
TL;DR: This work reviews one class of synthetic methods, direct condensation of a pre-formed aglycon unit with an appropriate sugar component, and its application in glycosylation of C-nucleosides.
Book
Proteinase and Peptidase Inhibition: Recent Potential Targets for Drug Development
H. John Smith,Claire Simons +1 more
TL;DR: The Urokinase-Type Plasminogen Activator System: A New Target for Tumor Therapy and Proteases of Protozoan Parasites for Proteinase Activity.
Journal ArticleDOI
Potent CYP19 (aromatase) 1-[(benzofuran-2-yl)(phenylmethyl)pyridine, -imidazole, and -triazole inhibitors: synthesis and biological evaluation.
Mohammed Reza Saberi,Tai Ky Vinh,Sook Wah Yee,B J Nathan Griffiths,Peter J. Evans,Claire Simons +5 more
TL;DR: The synthesis of a series of novel 1-[(benzofuran-2-yl)phenylmethyl]-pyridine, -imidazole, and -triazole derivatives is described, and negligible inhibitory activity was observed, suggesting a good selectivity for CYP19.