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Claire Simons

Researcher at Cardiff University

Publications -  96
Citations -  2337

Claire Simons is an academic researcher from Cardiff University. The author has contributed to research in topics: Docking (molecular) & Retinoic acid. The author has an hindex of 23, co-authored 90 publications receiving 2018 citations. Previous affiliations of Claire Simons include King Faisal Specialist Hospital & Research Centre & UCL Institute of Child Health.

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Journal ArticleDOI

Synthesis and biological evaluation of novel 2-deoxy-4-thio-imidazole nucleosides.

Y. Wang, +6 more
- 01 Mar 1999 - 
TL;DR: The para-nitrobenzoyl group gave the optimum result in the glycosylation step; therefore, this protected thiosugar 10b was used for the synthesis of a series of novel 2'-deoxy-4'-thio-imidazole nucleosides which have been evaluated for antiviral activity in vitro.
Journal ArticleDOI

Small-molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): synthesis and biological evaluation.

Salvatore Ferla, +7 more
- 08 Sep 2014 - 
TL;DR: Evaluation of binding affinity and inhibitory activity against CYP24A1 identified the imidazole styrylbenzamides as potent inhibitors of CYP 24A1, having selectivity with respect to CYP27B1 comparable with or greater than that of the standard ketoconazole.
Journal ArticleDOI

Small-Molecule Inhibitors Targeting Sterol 14α-Demethylase (CYP51): Synthesis, Molecular Modelling and Evaluation Against Candida albicans.

Faizah A Binjubair, +9 more
- 20 Jul 2020 - 
TL;DR: The extended series of novel azole derivatives, short and extended derivatives, designed, synthesised and investigated for CYP51 inhibitory activity, binding affinity and minimum inhibitory concentration against C. albicans strains are the better of the two series for further development.
Journal ArticleDOI

Novel retinoic acid 4-hydroxylase (CYP26) inhibitors based on a 3-(1H-imidazol- and triazol-1-yl)-2,2-dimethyl-3-(4-(phenylamino)phenyl)propyl scaffold.

Mohamed Gomaa, +7 more
- 15 Jul 2012 - 
TL;DR: The results demonstrate the potential for further development of these potent inhibitors and identify the most promising inhibitor methyl 2,2-dimethyl-3-(4-(phenylamino)phenyl)-3-(1H-1,2,4-triazol-1-yl)propanoate (6), which was further evaluated for CYP selectivity.
Reference BookDOI

Protein Misfolding in Neurodegenerative Diseases : Mechanisms and Therapeutic Strategies

H. John Smith, +2 more
TL;DR: Protein Folding and Misfolding, Relevance to Disease and Function Massimi Stefani Alzheimer's Disease Charlotte E. Teunissen and Tischa M. van der Cammen Improving Cholinergic Transmission Cholinerential Transmission and Acetylcholine release Enhancers Pierre Francotte, Pascal de Tullio and Bernard Pirotte AChE and its Inhibitors and their Clinical Assessment.