C
Clara Pereira
Researcher at University of Porto
Publications - 26
Citations - 925
Clara Pereira is an academic researcher from University of Porto. The author has contributed to research in topics: Yeast & Mitochondrion. The author has an hindex of 14, co-authored 26 publications receiving 838 citations. Previous affiliations of Clara Pereira include University of Minho & Instituto de Biologia Molecular e Celular.
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ADP/ATP carrier is required for mitochondrial outer membrane permeabilization and cytochrome c release in yeast apoptosis.
TL;DR: expression of a mutated form of Aac2p (op1) exhibiting very low ADP/ATP translocase activity indicates that AAC's pro‐death role does not require transloc enzyme activity, which points to a crucial role of AAC in yeast apoptosis.
Journal ArticleDOI
Mitochondria-dependent apoptosis in yeast.
Clara Pereira,Rui D. Silva,Lucília Saraiva,Björn Johansson,Maria João Sousa,Manuela Côrte-Real +5 more
TL;DR: Yeast with its distinctive ability to survive without respiration-competent mitochondria is a powerful model to study the involvement of mitochondria and mitochondria interacting proteins in cell death.
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Mitochondrial degradation in acetic acid‐induced yeast apoptosis: the role of Pep4 and the ADP/ATP carrier
Clara Pereira,Susana R. Chaves,Sara Alves,Bénédict Salin,Nadine Camougrand,Stéphen Manon,Maria João Sousa,Manuela Côrte-Real +7 more
TL;DR: It is shown that autophagy is not active in cells undergoing acetic acid‐induced apoptosis and is therefore not responsible for mitochondrial degradation, and it is found that the vacuolar protease Pep4p and the AAC proteins have a role in mitochondrial degradation using yeast genetic approaches.
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YCA1 participates in the acetic acid induced yeast programmed cell death also in a manner unrelated to its caspase-like activity
Nicoletta Guaragnella,Clara Pereira,Maria João Sousa,Lucia Antonacci,Salvatore Passarella,Manuela Côrte-Real,Ersilia Marra,Sergio Giannattasio +7 more
TL;DR: It is shown that Δyca1 cells undergo programmed cell death (PCD) with a rate lower than that of the WT and that PCD in WT cells is caused at least in part by the caspase activity of Yca1p.
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Contribution of Yeast Models to Neurodegeneration Research
TL;DR: Several yeast models that have contributed to the uncovering of the etiology and pathogenesis of several neurodegenerative diseases are described, including the most common forms of neuro degeneration worldwide, Alzheimer's, Parkinson's, and Huntington's diseases.