Manuela Côrte-Real

TL;DR: Results show that a programmed cell death process sharing common features with an apoptotic phenotype can be induced by acetic acid in S. cerevisiae, raising the possibility of this mode of cell death being more generalized in yeasts than previously considered and extended to cell death induced by other stress agents.

TL;DR: It is shown that the yeast AIF homologue Ynr074cp controls yeast apoptosis and is renamed AIF-1 (Aif1p, gene AIF1), a cell death effector in yeast, which is essential for normal mammalian development and participates in pathological apoptosis.

TL;DR: The understanding of the involvement of a mitochondria-dependent apoptotic pathway in S. cerevisiae PCD process will be most useful in the further elucidation of an ancestral pathway common to PCD in metazoans.

TL;DR: Evidence is presented that hyperosmotic stress caused by high glucose or sorbitol concentrations in culture medium induces in Saccharomyces cerevisiae a cell death process accompanied by morphological and biochemical indicators of apoptotic programmed cell death, namely chromatin condensation along the nuclear envelope.

TL;DR: expression of a mutated form of Aac2p (op1) exhibiting very low ADP/ATP translocase activity indicates that AAC's pro‐death role does not require transloc enzyme activity, which points to a crucial role of AAC in yeast apoptosis.