Clare Elizabeth Hughes

TL;DR: The results suggest that, in the osteoarthritis synovium, both inflammatory and destructive responses are dependent largely on macrophages and that these effects are cytokine-driven through a combination of IL-1 and TNF-α.

TL;DR: The results of this study indicate that cartilage SZP is homologous with a glycoprotein first described as the precursor protein of a megakaryocyte stimulating factor (MSF) and may play an important cytoprotective role by preventing cellular adhesion to the articular cartilage surface in normal cartilage metabolism.

TL;DR: An overview of some important recent findings concerning the ability of macrophages to drive inflammatory and destructive disease mechanisms in OA, the role of their proinflammatory cytokines in doing so, and the potential for Macrophages and macrophage-produced cytokines to be used as therapeutic targets for the development of disease-modifying anti-ostroarthritic drugs (DMOADs) are given.

TL;DR: These studies have clearly established that 'aggrecanase(s)' is primarily responsible for the catabolism and loss of aggrecan from articular cartilage in the early stages of arthritic joint diseases that precede overt collagen catabolisms and disruption of the tissue integrity.

TL;DR: Findings provide evidence that n-3 fatty acid supplementation can specifically affect regulatory mechanisms involved in chondrocyte gene transcription and thus further advocate a beneficial role for dietary fish oil supplementation in alleviation of several of the physiological parameters that cause and propogate arthritic disease.