C
Claude Beaudoin
Researcher at French Institute of Health and Medical Research
Publications - 8
Citations - 473
Claude Beaudoin is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Biology & Internal medicine. The author has an hindex of 4, co-authored 5 publications receiving 426 citations. Previous affiliations of Claude Beaudoin include Blaise Pascal University & Centre national de la recherche scientifique.
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Journal ArticleDOI
Metal-NHC complexes: a survey of anti-cancer properties
Marie-Laure Teyssot,Marie-Laure Teyssot,Anne-Sophie Jarrousse,Anne-Sophie Jarrousse,Michèle Manin,Michèle Manin,Aurélien Chevry,Aurélien Chevry,Stéphane P. Roche,Stéphane P. Roche,Frédéric Norre,Frédéric Norre,Claude Beaudoin,Claude Beaudoin,Laurent Morel,Laurent Morel,Damien Boyer,Damien Boyer,Rachid Mahiou,Rachid Mahiou,Arnaud Gautier,Arnaud Gautier +21 more
TL;DR: Most of the metal-N-Heterocyclic Carbenes considered display higher cytotoxicities than the reference metallo-drug cisplatin, and their mechanisms of action at the cellular level are discussed, showing that the nature of themetal is of great importance.
Journal ArticleDOI
Toxicity of Copper(I)-NHC Complexes Against Human Tumor Cells: Induction of Cell Cycle Arrest, Apoptosis, and DNA Cleavage
Marie-Laure Teyssot,Anne-Sophie Jarrousse,Aurélien Chevry,Angélique de Haze,Claude Beaudoin,Michèle Manin,Steven P. Nolan,Silvia Díez-González,Laurent Morel,Arnaud Gautier +9 more
TL;DR: Results of the biological evaluation of the anticancer properties of [(SIMes)CuCl] 5 evidenced that employing NHC to deliver active copper(I) species in cellulo is a valuable strategy in anticancer research.
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Monodisperse silica nanoparticles doped with dipicolinic acid-based luminescent lanthanide(III) complexes for bio-labelling
Claire Gaillard,Claire Gaillard,Pierre Adumeau,Pierre Adumeau,Jean-Louis Canet,Arnaud Gautier,Arnaud Gautier,Damien Boyer,Claude Beaudoin,Claude Beaudoin,Claude Beaudoin,Cédric Hesling,Cédric Hesling,Cédric Hesling,Laurent Morel,Laurent Morel,Laurent Morel,Rachid Mahiou,Rachid Mahiou +18 more
TL;DR: The facile synthesis of functionalized luminescent nanoparticles from LnL3 lanthanide complexes is described and the cytotoxicity of the nano-objects was investigated for a further application in bioimaging.
Journal ArticleDOI
Bile acids and male fertility: From mouse to human?
Lauriane Sédes,Emmanuelle Martinot,Emmanuelle Martinot,Emmanuelle Martinot,Marine Baptissart,Marine Baptissart,Marine Baptissart,Silvère Baron,Silvère Baron,Silvère Baron,Françoise Caira,Françoise Caira,Françoise Caira,Claude Beaudoin,Claude Beaudoin,Claude Beaudoin,David H. Volle,David H. Volle,David H. Volle +18 more
TL;DR: The studies on mouse models open perspectives to better understand the deleterious effects of bile acids on testicular pathophysiologies and fertility disorders and additional studies are needed to corroborate these correlations in humans.
Journal ArticleDOI
Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling Pathways in the Control of Undifferentiated Germ Cell Homeostasis and Chemoresistance
Laura Thirouard,Hélène Holota,Mélusine Monrose,Manon Garcia,Angélique de Haze,Christelle Damon-Soubeyrand,Yoan Renaud,Jean-Paul Saru,Alessia Perino,Kristina Schoonjans,Claude Beaudoin,David H. Volle +11 more
TL;DR: It is shown that Tgr5 plays key role on undifferentiated germ cell homeostasis and that modulating the TGR5 signaling pathway could be used as a potential therapeutic tool for fertility disorders.