C
Claude F. Meares
Researcher at University of California, Davis
Publications - 212
Citations - 9110
Claude F. Meares is an academic researcher from University of California, Davis. The author has contributed to research in topics: RNA polymerase & Radioimmunotherapy. The author has an hindex of 54, co-authored 212 publications receiving 8958 citations. Previous affiliations of Claude F. Meares include Lawrence Livermore National Laboratory & University of California.
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Journal ArticleDOI
Conjugation of antibodies with bifunctional chelating agents: Isothiocyanate and bromoacetamide reagents, methods of analysis, and subsequent addition of metal ions☆
Claude F. Meares,Michael J. McCall,Dayton T. Reardan,David A. Goodwin,David A. Goodwin,Carol I. Diamanti,Carol I. Diamanti,Maureen McTigue,Maureen McTigue +8 more
TL;DR: The labeled products retain their immunoreactivity, as illustrated by experiments in vivo with chelate-conjugated antibody to mouse I-AK antigen.
Journal ArticleDOI
Antibodies against metal chelates
Dayton T. Reardan,Claude F. Meares,David A. Goodwin,David A. Goodwin,Maureen McTigue,Maureen McTigue,Gary S. David,Mary R. Stone,Julia P. Leung,Richard M. Bartholomew,James M. Frincke +10 more
TL;DR: These antibodies show a remarkable preference for indium chelates; changing to another metal such as scandium or gallium can decrease the antibody-binding constant by more than three orders of magnitude, which introduces a new degree of control over the biological distributions of chelated radionuclides.
Journal Article
Pre-targeted immunoscintigraphy of murine tumors with indium-111-labeled bifunctional haptens.
TL;DR: A method of tumor imaging utilizing the nonspecific accumulation of antibody through leaky capillaries is described, in which the antibody and the radiolabel are administered separately.
Journal ArticleDOI
Copper chelates as probes of biological systems: Stable copper complexes with a macrocyclic bifunctional chelating agent
TL;DR: The synthesis of a new "bifunctional" metal chelator, 6(p-bromoacetamidobenzyl)-1,4,8,11-tetraazacyclotetradecane- N,N',N",N"' -Tetraacetic acid, which can be covalently attached to proteins and which binds copper stably in human serum under physiological conditions.
Journal ArticleDOI
The peptide way to macrocyclic bifunctional chelating agents: synthesis of 2-(p-nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N",N'''-tetraacetic acid and study of its yttrium(III) complex.
TL;DR: A new synthetic route to these macrocycles via peptide synthesis and intramolecular tosylamide ring closure is developed, performed in very dilute solution, eliminating concerns about polymer formation.