C
Claudia Schmidt
Researcher at Braunschweig University of Technology
Publications - 32
Citations - 694
Claudia Schmidt is an academic researcher from Braunschweig University of Technology. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 12, co-authored 22 publications receiving 455 citations. Previous affiliations of Claudia Schmidt include Technische Universität München.
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Journal ArticleDOI
Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram‐Positive Directed Antibacterial Effects
Claudia Schmidt,Bianka Karge,Rainer Misgeld,Aram Prokop,Raimo Franke,Mark Brönstrup,Ingo Ott +6 more
TL;DR: Gold complexes with N-heterocyclic carbene (NHC) ligands represent a promising class of metallodrugs for the treatment of cancer or infectious diseases, and antibacterial screening of the gold complexes showed a particularly high activity against Gram-positive strains, reflecting their high dependence on an intact Trx/TrxR system.
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Biscarbene gold(I) complexes: structure–activity-relationships regarding antibacterial effects, cytotoxicity, TrxR inhibition and cellular bioavailability
TL;DR: A series of gold(i) complexes with two N-heterocyclic carbene ligands (biscarbene gold complexes) were prepared and evaluated for their effects against cancer cells and pathogenic bacteria and indicated a strong correlation between cellular bioavailability and antiproliferative effects.
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A chemical-biological evaluation of rhodium(I) N-heterocyclic carbene complexes as prospective anticancer drugs.
Luciano Oehninger,Laura Nadine Küster,Claudia Schmidt,Alvaro Muñoz-Castro,Aram Prokop,Ingo Ott +5 more
TL;DR: Overall, these studies indicated that Rh(I)-NHC fragments could be used as partial structures of new antitumor agents, in particular in those drugs designed to address resistant malignant tissues.
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Synthesis, Cellular Uptake and Biological Activity Against Pathogenic Microorganisms and Cancer Cells of Rhodium and Iridium N‐Heterocyclic Carbene Complexes Bearing Charged Substituents
TL;DR: Four new N-heterocyclic carbene rhodium and iridium complexes decorated with anionic or cationic pendant groups to increase their water solubility and biological activity have been synthesised and characterised and cellular uptake studies clearly confirmed that the cationIC phosphonium groups facilitated uptake, which was linked with higher biological activity.
Journal ArticleDOI
A gold(I) biscarbene complex with improved activity as a TrxR inhibitor and cytotoxic drug: comparative studies with different gold metallodrugs
Claudia Schmidt,Lucia Albrecht,Shantheya Balasupramaniam,Rainer Misgeld,Bianka Karge,Mark Brönstrup,Aram Prokop,Knut Baumann,Stephan Reichl,Ingo Ott +9 more
TL;DR: The novel (NHC)2Au+ complex exhibits substantially lower protein binding in combination with a strongly enhanced cytotoxic activity and represents a substantially improved and selective TrxR inhibitor compared to close structural analogues.