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Claudia Schmidt
Researcher at Braunschweig University of Technology
Publications - 32
Citations - 694
Claudia Schmidt is an academic researcher from Braunschweig University of Technology. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 12, co-authored 22 publications receiving 455 citations. Previous affiliations of Claudia Schmidt include Technische Universität München.
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Journal ArticleDOI
Multi-stimuli responsive block copolymers as a smart release platform for a polypyridyl ruthenium complex
Michael Appold,Cristina Mari,Christina Lederle,Johannes Elbert,Claudia Schmidt,Ingo Ott,Bernd Stühn,Gilles Gasser,Markus Gallei +8 more
TL;DR: In this paper, the synthesis and structure formation of block copolymers (BCPs) consisting of poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) as one segment and poly(methyl metha-b-PMMA) or a statistical copolymer as a second segment is described.
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Cyclometallated Au(III) dithiocarbamate complexes: synthesis, anticancer evaluation and mechanistic studies
Morwen Williams,Benoît Bertrand,Benoît Bertrand,David L. Hughes,Zoë A. E. Waller,Claudia Schmidt,Ingo Ott,Maria A. O'Connell,Mark Searcey,Manfred Bochmann +9 more
TL;DR: A series of cationic mixed cyclometallated (C^N)Au(iii) dithiocarbamate complexes has been synthesized and appeared to be susceptible to reduction by glutathione but were stable in the presence of N-acetyl cysteine.
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Synthesis, structure and cytotoxicity of cyclic (alkyl)(amino) carbene and acyclic carbene complexes of group 11 metals
Benoît Bertrand,Alexander S. Romanov,Mark Brooks,Josh Davis,Claudia Schmidt,Ingo Ott,Maria A. O'Connell,Manfred Bochmann +7 more
TL;DR: The mechanism of cell growth control by these complexes remains to be established, although possible modes of action such as inhibition of thioredoxin reductase (TrxR), or the formation of reactive oxygen species (ROS) through redox processes, could be ruled out as primary pathways.
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In Vitro and In Vivo Investigations into the Carbene Gold Chloride and Thioglucoside Anticancer Drug Candidates NHC-AuCl and NHC-AuSR
Wolfgang Walther,Oyinlola Dada,Cillian O'Beirne,Ingo Ott,Goar Sánchez-Sanz,Claudia Schmidt,Carsta Werner,Xiangming Zhu,Matthias Tacke +8 more
TL;DR: The anticancer drug candidate 1,3-dibenzyl-4,5-diphenyl-imidazol-2-ylidene gold(I) chloride and its NHC-AuSR showed very good activity against a wide range of human cancer cell lines inclusive renal cell cancer with similar average GI50 values, which seems to indicate that apoptosis induction through elevated oxidative stress is the main mechanism for the two gold compounds.
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A Multitarget Gold(I) Complex Induces Cytotoxicity Related to Aneuploidy in HCT-116 Colorectal Carcinoma Cells.
Jing-Jing Zhang,Jing-Jing Zhang,Jing-Jing Zhang,Mohamed A. Abu el Maaty,Henrik Hoffmeister,Claudia Schmidt,Julienne K. Muenzner,Rainer Schobert,Stefan Wölfl,Ingo Ott +9 more
TL;DR: Induction of aneuploidy beyond a critical level can provide an effective strategy to target cancer, in particular colorectal tumours with a low tolerance of anauploids, and could be of relevance for 1 and other metallodrugs.