Claus Metzner

TL;DR: The authors' measurements show that breast carcinoma cells cultured in collagen gels generated nearly constant forces regardless of the collagen concentration and matrix stiffness, and time-lapse force measurements showed that these cells migrated in a gliding motion with alternating phases of high and low contractility, elongation, migratory speed and persistence.

TL;DR: The data show that the ability to overcome the steric hindrance of the matrix cannot be attributed to a single cell property but instead arises from a combination of adhesiveness, nuclear volume, contractility, and cell stiffness.

TL;DR: It is found that the pore size decreases with the square root of the concentration, consistent with a total fiber length that scales linearly with concentration.

TL;DR: A new approach to migration trajectories of tumour cells in two and three dimensions is applied, and the superior ability of the superstatistical method to discriminate cell migration strategies in different environments is demonstrated.

TL;DR: The findings suggest that the spontaneous motion of CSK-bound beads is driven not by random, local stress fluctuations within a viscoelastic continuum or cage, but rather by stress fluctuationsWithin a tensed and constantly remodeling CSK network that transmits stresses over considerable distances to the ECM.