C
Clemens Sommer
Researcher at University of Mainz
Publications - 163
Citations - 8349
Clemens Sommer is an academic researcher from University of Mainz. The author has contributed to research in topics: AMPA receptor & Receptor. The author has an hindex of 41, co-authored 155 publications receiving 7380 citations. Previous affiliations of Clemens Sommer include University of Ulm & Heidelberg University.
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Journal ArticleDOI
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
Arthur Liesz,Elisabeth Suri-Payer,Claudia Veltkamp,Henrike Doerr,Clemens Sommer,Serge Rivest,Thomas Giese,Roland Veltkamp +7 more
TL;DR: Treg cells are major cerebroprotective modulators of postischemic inflammatory brain damage targeting multiple inflammatory pathways, and IL-10 signaling is essential for their immunomodulatory effect.
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The hematopoietic factor G-CSF is a neuronal ligand that counteracts programmed cell death and drives neurogenesis
Armin Schneider,Carola Krüger,Tobias Steigleder,Tobias Steigleder,Tobias Steigleder,Daniela Weber,Claudia Pitzer,Rico Laage,Jaroslaw Aronowski,Martin H. Maurer,Nikolaus Gassler,Walter Mier,Martin Hasselblatt,Rainer Kollmar,Stefan Schwab,Clemens Sommer,Bach Alfred,Hans-Georg Kuhn,Hans-Georg Kuhn,Wolf Rüdiger Schäbitz,Wolf Rüdiger Schäbitz +20 more
TL;DR: G-CSF markedly improved long-term behavioral outcome after cortical ischemia, while stimulating neural progenitor response in vivo, providing a link to functional recovery, and is proposed as a potential new drug for stroke and neurodegenerative diseases.
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Neuroprotective effect of granulocyte colony-stimulating factor after focal cerebral ischemia.
W.R. Schäbitz,Rainer Kollmar,Markus Schwaninger,Eric Juettler,Jürgen Bardutzky,Marion N. Schölzke,Clemens Sommer,Stefan Schwab +7 more
TL;DR: G-CSF achieved a significant neuroprotective effect in cell culture and after intravenous administration after stroke, and increased STAT3 expression in the penumbra of G- CSF–treated rats suggests mediation by G-CSFR.
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Intravenous Brain-Derived Neurotrophic Factor Enhances Poststroke Sensorimotor Recovery and Stimulates Neurogenesis
Wolf-Rüdiger Schäbitz,Tobias Steigleder,Christiana M. Cooper-Kuhn,Stefan Schwab,Clemens Sommer,Armin Schneider,H. Georg Kuhn +6 more
TL;DR: The role of BDNF is consolidated as a modulator of neurogenesis in the brain and as an enhancer of long-term functional neurological outcome after cerebral ischemia.
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Ischemic stroke: experimental models and reality
TL;DR: The two models mimicking human stroke most closely are various embolic stroke models and spontaneous stroke models, which more closely mimics the therapeutic situation of mechanical thrombectomy which is expected to be increasingly applied to stroke patients.