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Arthur Liesz
Researcher at Ludwig Maximilian University of Munich
Publications - 93
Citations - 6874
Arthur Liesz is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Brain ischemia & Stroke. The author has an hindex of 35, co-authored 76 publications receiving 4783 citations. Previous affiliations of Arthur Liesz include Klinikum der Universität München & German Cancer Research Center.
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Journal ArticleDOI
Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke
Arthur Liesz,Elisabeth Suri-Payer,Claudia Veltkamp,Henrike Doerr,Clemens Sommer,Serge Rivest,Thomas Giese,Roland Veltkamp +7 more
TL;DR: Treg cells are major cerebroprotective modulators of postischemic inflammatory brain damage targeting multiple inflammatory pathways, and IL-10 signaling is essential for their immunomodulatory effect.
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Microbiota Dysbiosis Controls the Neuroinflammatory Response after Stroke.
Vikramjeet Singh,Stefan Roth,Gemma Llovera,Rebecca Sadler,Debora Garzetti,Bärbel Stecher,Martin Dichgans,Arthur Liesz +7 more
TL;DR: It is shown by next-generation sequencing that large stroke lesions cause gut microbiota dysbiosis, which in turn affects stroke outcome via immune-mediated mechanisms, and that the gut microbiota is a central regulator of immune homeostasis.
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Inhibition of lymphocyte trafficking shields the brain against deleterious neuroinflammation after stroke.
Arthur Liesz,Wei Zhou,Eva Mracsko,Simone Karcher,Henrike Bauer,Sönke Schwarting,Li Sun,Dunja Bruder,Sabine Stegemann,Adelheid Cerwenka,Clemens Sommer,Alexander H. Dalpke,Roland Veltkamp +12 more
TL;DR: Targeting T lymphocyte-migration represents a promising therapeutic approach for ischaemic stroke by inhibiting leukocyte very late antigen-4 and endothelial vascular cell adhesion molecule-1-mediated brain invasion, currently the most effective strategy in primary neuroinflammatory brain disease in murine ischaemia stroke models.
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Hemostatic Therapy in Experimental Intracerebral Hemorrhage Associated With the Direct Thrombin Inhibitor Dabigatran
Wei Zhou,Sönke Schwarting,Sergio Illanes,Arthur Liesz,Moritz Middelhoff,Markus Zorn,Martin Bendszus,Sabine Heiland,Joanne van Ryn,Roland Veltkamp +9 more
TL;DR: There is strong evidence that PCC and, less consistently, fresh-frozen plasma prevent excess intracerebral hematoma expansion in a murine ICH model associated with dabigatran, and the efficacy and safety of this strategy must be further evaluated in clinical studies.
Journal ArticleDOI
Microglia monitor and protect neuronal function through specialized somatic purinergic junctions
Csaba Cserép,Balázs Pósfai,Nikolett Lénárt,Rebeka Fekete,Zsófia I. László,Zsolt Lele,Barbara Orsolits,Gábor Molnár,Steffanie Heindl,Anett D. Schwarcz,Katinka Ujvári,Zsuzsanna Környei,Krisztina Tóth,Eszter Szabadits,Beáta Sperlágh,Mária Baranyi,László Csiba,Tibor Hortobágyi,Tibor Hortobágyi,Tibor Hortobágyi,Zsófia Maglóczky,Bernadett Martinecz,Gábor Szabó,Ferenc Erdélyi,Róbert Szipőcs,Michael M. Tamkun,Benno Gesierich,Marco Duering,István Katona,Arthur Liesz,Gábor Tamás,Adam Denes +31 more
TL;DR: The junctions appear to provide a major site for microglia-neuron communication and may help to mediate the neuroprotective effects ofmicroglia after acute brain injury, and microglial processes at these junctions could potentially monitor and protect neuronal functions.