Cleudiomar Inácio Lino

TL;DR: Molecular modeling studies results corroborated experimental SAR results, suggesting their use in the design of new antifungal agents, suggesting high selectivity.

TL;DR: The discovery of novel thiazole compounds, which are easy to synthesize, and with potentially exhibit antifungal activity, and display low cytotoxicity in normal mammalian cells are revealed.

TL;DR: It is shown that the action of these thiazole compounds 1, 2, 3, and 4 is related to an interference with the antioxidant system, which suggests that oxidative stress may be primarily related to the accumulation of superoxide radicals.

TL;DR: Results show that thiazolylhydrazones are an antifungal towards C. albicans with in vivo efficacy, and they prolonged larval survival when tested between 5 and 15 mg/kg, performing as well as fluconazole.

TL;DR: In in vivo experiments, significant differences were detected in uric acid, alkaline phosphatase, ALT, and urea, indicating a possible antioxidant protective role of such substances in the liver and kidney of diabetic animals that could be acting by means other than that commonly reported in the literature.