Journal ArticleDOI
Synthesis, molecular modeling studies and evaluation of antifungal activity of a novel series of thiazole derivatives
Cleudiomar Inácio Lino,Igor Gonçalves de Souza,Beatriz M. Borelli,Thelma Tirone Silvério Matos,Iasmin Natália Santos Teixeira,Jonas Pereira Ramos,Elaine Maria de Souza Fagundes,Philipe de Oliveira Fernandes,Vinícius Gonçalves Maltarollo,Susana Johann,Renata Barbosa de Oliveira +10 more
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TLDR
Molecular modeling studies results corroborated experimental SAR results, suggesting their use in the design of new antifungal agents, suggesting high selectivity.About:
This article is published in European Journal of Medicinal Chemistry.The article was published on 2018-05-10. It has received 90 citations till now. The article focuses on the topics: Minimum inhibitory concentration.read more
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New Series of Thiazole Derivatives: Synthesis, Structural Elucidation, Antimicrobial Activity, Molecular Modeling and MOE Docking.
Ismail Althagafi,Nashwa M. El-Metwaly,Nashwa M. El-Metwaly,Thoraya A. Farghaly,Thoraya A. Farghaly +4 more
TL;DR: The potency of these compounds as antimicrobial agents has been evaluated and results showed that derivatives which have di- and trithiazole rings displayed high activity that exceeds the used standard antibiotic.
Journal ArticleDOI
Thiazole in the targeted anticancer drug discovery.
TL;DR: This review provides an overview of recent advances in thiazole-bearing compounds as anticancer agents with particular emphasis on their mechanism of action in cancerous cells.
Journal ArticleDOI
Thiazole Ring-A Biologically Active Scaffold.
TL;DR: A literature survey regarding the topics from the year 2015 up to now was carried out as mentioned in this paper, where nearly 124 research articles were found, critically analyzed, and arranged regarding the synthesis and biological activities of thiazoles derivatives in the last 5 years.
Journal ArticleDOI
Systematic in vitro comparison of decellularization protocols for blood vessels.
Robin Simsa,Arvind Manikantan Padma,Philipp Heher,Mats Hellström,Andreas H. Teuschl,Lachmi Jenndahl,Niklas Bergh,Per Fogelstrand +7 more
TL;DR: Comparing the decellularization and recellularization efficacy of 5 different protocols utilizing the detergents sodium dodecyl sulfate, sodium deoxycholate, SDS, SDC, CHAPS and TritonX together with DNA-removing enzymes on porcine vena cava in a perfusion bioreactor setup found that all protocols could efficiently de cellularize blood vessels.
Journal ArticleDOI
Derivatives of pyridine and thiazole hybrid: Synthesis, DFT, biological evaluation via antimicrobial and DNA cleavage activity.
TL;DR: The most obvious findings to emerge from this study are that on the basis of both biological activity and chemical reactivity 4-pyridine thiazole hybrid compounds 4a-e showed more potent activity than 3a- e.
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Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America
Peter G. Pappas,Carol A. Kauffman,David R. Andes,Cornelius J. Clancy,Kieren A. Marr,Luis Ostrosky-Zeichner,Annette C. Reboli,Mindy G. Schuster,Jose A. Vazquez,Thomas J. Walsh,Theoklis E. Zaoutis,Jack D. Sobel +11 more
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PaDEL‐descriptor: An open source software to calculate molecular descriptors and fingerprints
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Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking
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