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Clifford D.L. Folmes
Researcher at Mayo Clinic
Publications - 47
Citations - 5610
Clifford D.L. Folmes is an academic researcher from Mayo Clinic. The author has contributed to research in topics: Induced pluripotent stem cell & Stem cell. The author has an hindex of 28, co-authored 44 publications receiving 4679 citations. Previous affiliations of Clifford D.L. Folmes include University of Alberta & University of Winnipeg.
Papers
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Journal ArticleDOI
Myocardial Fatty Acid Metabolism in Health and Disease
TL;DR: The regulation of myocardial fatty acid beta-oxidation is reviewed and how alterations in fatty acid Beta-Oxidation can contribute to heart disease is discussed.
Journal ArticleDOI
Somatic oxidative bioenergetics transitions into pluripotency-dependent glycolysis to facilitate nuclear reprogramming
Clifford D.L. Folmes,Timothy J. Nelson,Almudena Martinez-Fernandez,D. Kent Arrell,Jelena Zlatkovic Lindor,Petras P. Dzeja,Yasuhiro Ikeda,Carmen Perez-Terzic,Andre Terzic +8 more
TL;DR: The energetic infrastructure of somatic cells transitions into a required glycolytic metabotype to fuel induction of pluripotency, and metaboproteomics resolved upregulated gly colytic enzymes and downregulated electron transport chain complex I subunits underlying cell fate determination.
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Metabolic plasticity in stem cell homeostasis and differentiation.
TL;DR: Recent progress is covered establishing an emerging relationship between stem cell metabolism and cell fate control, which offers a potential target for controlling tissue homeostasis and regeneration in aging and disease.
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Cardiac Energy Metabolism in Obesity
TL;DR: Optimizing cardiac energy metabolism in obese subjects may be one approach to preventing and treating cardiac dysfunction that can develop in this population.
Journal ArticleDOI
Glycolytic Stimulation Is Not a Requirement for M2 Macrophage Differentiation.
Feilong Wang,Song Zhang,Ivan Vuckovic,Ryoung-Hoon Jeon,Amir Lerman,Clifford D.L. Folmes,Petras P. Dzeja,Joerg Herrmann +7 more
TL;DR: It is demonstrated that 2-DG impairs oxidative phosphorylation and significantly reduces 13C-labeled Krebs cycle metabolites and intracellular ATP levels, and that glycolytic stimulation is not required for M2 macrophage differentiation as long as oxidative phosphate remains active.