Metabolic plasticity in stem cell homeostasis and differentiation.
Reads0
Chats0
TLDR
Recent progress is covered establishing an emerging relationship between stem cell metabolism and cell fate control, which offers a potential target for controlling tissue homeostasis and regeneration in aging and disease.About:
This article is published in Cell Stem Cell.The article was published on 2012-11-02 and is currently open access. It has received 571 citations till now. The article focuses on the topics: Cell Fate Control & Tissue homeostasis.read more
Citations
More filters
Journal ArticleDOI
NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice
Hongbo Zhang,Dongryeol Ryu,Yibo Wu,Karim Gariani,Xu Wang,Peiling Luan,Davide D'Amico,Eduardo R. Ropelle,Eduardo R. Ropelle,Matthias P. Lutolf,Ruedi Aebersold,Ruedi Aebersold,Kristina Schoonjans,Keir J. Menzies,Keir J. Menzies,Johan Auwerx +15 more
TL;DR: It is demonstrated the importance of the amount of the oxidized form of cellular nicotinamide adenine dinucleotide (NAD+) and its effect on mitochondrial activity as a pivotal switch to modulate muscle SC (MuSC) senescence and it is demonstrated that NR delays senescences of neural SCs and melanocyteSCs and increases mouse life span.
Journal ArticleDOI
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway
Anna Stincone,Alessandro Prigione,Thorsten Cramer,Mirjam M.C. Wamelink,Kate Campbell,Eric Cheung,Viridiana Olin-Sandoval,Nana-Maria Grüning,Antje Krüger,Mohammad Tauqeer Alam,Markus A. Keller,Michael Breitenbach,Kevin M. Brindle,Joshua D. Rabinowitz,Markus Ralser,Markus Ralser +15 more
TL;DR: The pentose phosphate pathway (PPP) is a fundamental component of cellular metabolism as discussed by the authors, which shares reactions with the Entner-Doudoroff pathway and the Calvin cycle and divides into an oxidative and non-oxidative branch.
Journal ArticleDOI
Stem cells and the impact of ROS signaling
TL;DR: It is concluded that ROS signaling is an emerging key regulator of multiple stem cell populations and the implications for reprogramming and stem cell ageing are discussed.
Journal ArticleDOI
A little sugar goes a long way: The cell biology of O-GlcNAc
Michelle R. Bond,John A. Hanover +1 more
TL;DR: The enzymes of O-GlcNAc cycling act preferentially on intrinsically disordered domains of target proteins impacting transcription, metabolism, apoptosis, organelle biogenesis, and transport.
Journal ArticleDOI
Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal
TL;DR: The emerging roles for metabolism in PSC self-renewal, differentiation, and reprogramming are discussed, with metabolite levels influencing epigenetic/genetic programs.
References
More filters
Journal ArticleDOI
Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors.
TL;DR: Induction of pluripotent stem cells from mouse embryonic or adult fibroblasts by introducing four factors, Oct3/4, Sox2, c-Myc, and Klf4, under ES cell culture conditions is demonstrated and iPS cells, designated iPS, exhibit the morphology and growth properties of ES cells and express ES cell marker genes.
Journal ArticleDOI
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
TL;DR: It is proposed that the metabolism of cancer cells, and indeed all proliferating cells, is adapted to facilitate the uptake and incorporation of nutrients into the biomass needed to produce a new cell.
Journal ArticleDOI
Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions
Chunaram Choudhary,Chanchal Kumar,Florian Gnad,Michael L. Nielsen,Michael Rehman,Tobias C. Walther,Jesper V. Olsen,Matthias Mann +7 more
TL;DR: A proteomic-scale analysis of protein acetylation suggests that it is an important biological regulatory mechanism and the regulatory scope of lysine acetylations is broad and comparable with that of other major posttranslational modifications.
Journal ArticleDOI
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
David E. Harrison,Randy Strong,Zelton D Sharp,James F. Nelson,Clinton M. Astle,Kevin Flurkey,Nancy L. Nadon,J. Erby Wilkinson,Krystyna Frenkel,Christy S. Carter,Christy S. Carter,Marco Pahor,Marco Pahor,Martin A. Javors,Elizabeth Fernandez,Richard A. Miller +15 more
TL;DR: It is reported that rapamycin, an inhibitor of the mTOR pathway, extends median and maximal lifespan of both male and female mice when fed beginning at 600 days of age.
Journal ArticleDOI
Evidence for cardiomyocyte renewal in humans
Olaf Bergmann,Ratan D. Bhardwaj,Samuel Bernard,Sofia Zdunek,Fanie Barnabé-Heider,Stuart Walsh,Joel Zupicich,Kanar Alkass,Bruce A. Buchholz,Henrik Druid,Stefan Jovinge,Jonas Frisén +11 more
TL;DR: The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.