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Colin R. Butler
Researcher at UCL Institute of Child Health
Publications - 8
Citations - 212
Colin R. Butler is an academic researcher from UCL Institute of Child Health. The author has contributed to research in topics: Respiratory epithelium & Innate immune system. The author has an hindex of 6, co-authored 8 publications receiving 148 citations. Previous affiliations of Colin R. Butler include Great Ormond Street Hospital for Children NHS Foundation Trust & University College London.
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Journal ArticleDOI
Tracheal Replacement Therapy with a Stem Cell‐Seeded Graft: Lessons from Compassionate Use Application of a GMP‐Compliant Tissue‐Engineered Medicine
Martin Elliott,Colin R. Butler,Colin R. Butler,Aikaterini Varanou-Jenkins,Leanne Partington,Carla Carvalho,Edward R. Samuel,Claire Crowley,Peggy Lange,Nicholas Hamilton,Robert E. Hynds,Tahera Ansari,Paul Sibbons,Anja Fierens,Claire McLaren,Derek J. Roebuck,C Wallis,Nagarajan Muthialu,Richard Hewitt,David Crabbe,Sam M. Janes,Paolo De Coppi,Mark W. Lowdell,Martin A. Birchall +23 more
TL;DR: An acute event, hypothesized to be an intrathoracic bleed, caused sudden airway obstruction 3 weeks post‐transplantation, resulting in the death of the recipient, and the practical difficulties in delivering GMP grafts underscore the need to refine protocols for phase I clinical trials.
Journal ArticleDOI
Vacuum-assisted decellularization: an accelerated protocol to generate tissue-engineered human tracheal scaffolds
Colin R. Butler,Robert E. Hynds,Claire Crowley,Kate H.C. Gowers,Leanne Partington,Nicholas Hamilton,Carla Carvalho,Manuela Platé,Edward R. Samuel,Alan J. Burns,Luca Urbani,Martin A. Birchall,Mark W. Lowdell,Paolo De Coppi,Sam M. Janes +14 more
TL;DR: It is concluded that the substantial reduction in time required to produce scaffolds using VAD compared to DEM does not compromise the quality of human tracheal scaffold generated and might inform clinical decellularization techniques as VAD offers accelerated scaffold production and reduces the associated costs.
Journal ArticleDOI
Practical insights for paediatric otolaryngology surgical cases and performing microlaryngobronchoscopy during the COVID-19 pandemic.
Claire Frauenfelder,Colin R. Butler,Ben Hartley,L.A. Cochrane,Chris Jephson,Robert Nash,Richard Hewitt,David M. Albert,Michelle Wyatt,Andrew Hall +9 more
TL;DR: Guidelines for operating on paediatric otolaryngological patients when necessary during the COVID-19 pandemic are presented, and experience gathered during microlaryngobronchoscopy on a CO VID-19 positive infant is incorporated.
Journal ArticleDOI
Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds
Nicholas Hamilton,Nicholas Hamilton,Dani Do Hyang Lee,Kate H.C. Gowers,Colin R. Butler,Elizabeth F. Maughan,Benjamin Jevans,Jessica C. Orr,Conor J. McCann,Alan J. Burns,Sheila MacNeil,Martin A. Birchall,Christopher O'Callaghan,Robert E. Hynds,Sam M. Janes +14 more
TL;DR: The results demonstrate the feasibility of generating HBEC grafts on clinically applicable decellularised dermis scaffolds and identify matrix proteins and integrins important for this process and identify those important for the long-term survivability of pre-differentiated epithelia.
Posted ContentDOI
Cell-intrinsic differences between human airway epithelial cells from children and adults
Elizabeth F. Maughan,Ersilia Nigro,Adam Pennycuick,Kate H.C. Gowers,Celine Denais,Sandra Gómez-López,Kyren A. Lazarus,Colin R. Butler,Colin R. Butler,Dani Do Hyang Lee,Jessica C. Orr,Vitor H. Teixeira,Benjamin Hartley,Richard Hewitt,Chadwan Al Yaghchi,G.S. Sandhu,Martin A. Birchall,Christopher O'Callaghan,Claire Smith,Paolo De Coppi,Robert E. Hynds,Sam M. Janes +21 more
TL;DR: It is found that, while the cellular composition of the paediatric and adult tracheobronchial epithelium is broadly similar, in cell culture, paediatric airway epithelial cells displayed higher colony forming ability, better in vitro growth and outcompeted adult cells in competitive proliferation assays.