Kate H.C. Gowers

TL;DR: The Human Tumor Atlas Network (HTAN), part of the NCI Cancer Moonshot Initiative, will establish a clinical, experimental, computational, and organizational framework to generate informative and accessible three-dimensional atlases of cancer transitions for a diverse set of tumor types.

TL;DR: W Whole-genome sequencing of normal bronchial epithelium from 16 individuals shows that tobacco smoking increases genomic heterogeneity, mutational burden and driver mutations, whereas stopping smoking promotes replenishment of the epithelia with near-normal cells.

TL;DR: The authors' method generates large numbers of functional airway basal epithelial cells with the efficiency demanded by clinical transplantation, suggesting its suitability for use in tracheal reconstruction.

TL;DR: TRAIL delivery by MSC-derived EVs is an effective anticancer therapy, and this effect could be further enhanced using a CDK9 inhibitor.

TL;DR: It is concluded that the substantial reduction in time required to produce scaffolds using VAD compared to DEM does not compromise the quality of human tracheal scaffold generated and might inform clinical decellularization techniques as VAD offers accelerated scaffold production and reduces the associated costs.