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Dani Do Hyang Lee
Researcher at UCL Institute of Child Health
Publications - 11
Citations - 342
Dani Do Hyang Lee is an academic researcher from UCL Institute of Child Health. The author has contributed to research in topics: Respiratory epithelium & Transplantation. The author has an hindex of 5, co-authored 10 publications receiving 241 citations. Previous affiliations of Dani Do Hyang Lee include Great Ormond Street Hospital & University College London.
Papers
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Journal ArticleDOI
Rapid Expansion of Human Epithelial Stem Cells Suitable for Airway Tissue Engineering
Colin R. Butler,Robert E. Hynds,Kate H.C. Gowers,Dani Do Hyang Lee,James Brown,Claire Crowley,Vitor H. Teixeira,Claire Smith,Luca Urbani,Nicholas Hamilton,Ricky Thakrar,Helen Booth,Martin A. Birchall,Paolo De Coppi,Adam Giangreco,Christopher O'Callaghan,Sam M. Janes +16 more
TL;DR: The authors' method generates large numbers of functional airway basal epithelial cells with the efficiency demanded by clinical transplantation, suggesting its suitability for use in tracheal reconstruction.
Journal ArticleDOI
Evidence of Respiratory Syncytial Virus Spread by Aerosol. Time to Revisit Infection Control Strategies
Hemant Kulkarni,Claire Smith,Dani Do Hyang Lee,Robert A. Hirst,Andrew J. Easton,Christopher O'Callaghan +5 more
TL;DR: It is shown for the first time that infants with RSV-positive bronchiolitis nursed in a ward setting or ventilated in intensive care produced large numbers of aerosol particles containing RSV that remained infectious and were capable of infecting healthy and COPD human ciliated epithelium.
Book ChapterDOI
Ciliated Epithelial Cell Differentiation at Air-Liquid Interface Using Commercially Available Culture Media.
TL;DR: Overall, the specific differentiation medium used in the air-liquid interface culture protocol was not a major determinant of ciliation, and the data suggest that the differentiation potential of basal cells at the outset is a more critical factor in air- liquid interface culture outcome.
Journal ArticleDOI
Bioengineered airway epithelial grafts with mucociliary function based on collagen IV- and laminin-containing extracellular matrix scaffolds
Nicholas Hamilton,Nicholas Hamilton,Dani Do Hyang Lee,Kate H.C. Gowers,Colin R. Butler,Elizabeth F. Maughan,Benjamin Jevans,Jessica C. Orr,Conor J. McCann,Alan J. Burns,Sheila MacNeil,Martin A. Birchall,Christopher O'Callaghan,Robert E. Hynds,Sam M. Janes +14 more
TL;DR: The results demonstrate the feasibility of generating HBEC grafts on clinically applicable decellularised dermis scaffolds and identify matrix proteins and integrins important for this process and identify those important for the long-term survivability of pre-differentiated epithelia.
Posted ContentDOI
Cell-intrinsic differences between human airway epithelial cells from children and adults
Elizabeth F. Maughan,Ersilia Nigro,Adam Pennycuick,Kate H.C. Gowers,Celine Denais,Sandra Gómez-López,Kyren A. Lazarus,Colin R. Butler,Colin R. Butler,Dani Do Hyang Lee,Jessica C. Orr,Vitor H. Teixeira,Benjamin Hartley,Richard Hewitt,Chadwan Al Yaghchi,G.S. Sandhu,Martin A. Birchall,Christopher O'Callaghan,Claire Smith,Paolo De Coppi,Robert E. Hynds,Sam M. Janes +21 more
TL;DR: It is found that, while the cellular composition of the paediatric and adult tracheobronchial epithelium is broadly similar, in cell culture, paediatric airway epithelial cells displayed higher colony forming ability, better in vitro growth and outcompeted adult cells in competitive proliferation assays.