C
Constance M. Vadheim
Researcher at University of California, Irvine
Publications - 8
Citations - 1682
Constance M. Vadheim is an academic researcher from University of California, Irvine. The author has contributed to research in topics: Population & Crohn's disease. The author has an hindex of 7, co-authored 8 publications receiving 1635 citations.
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Journal Article
Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives
Daniel Hollander,Constance M. Vadheim,Edward Brettholz,Gloria M. Petersen,Thomas Delahunty,Jerome I. Rotter +5 more
TL;DR: The twofold increase in permeability of patients and their relatives indicates that the intestinal defect in the ability to exclude larger sized molecules is not secondary to clinically recognized intestinal inflammation, but is a primary defect that may be an etiologic factor in this disease.
Journal ArticleDOI
Increased Intestinal Permeability in Patients with Crohn's Disease and Their Relatives: A Possible Etiologic Factor
Daniel Hollander,Constance M. Vadheim,Edward Brettholz,Gloria M. Petersen,Thomas Delahunty,Jerome I. Rotter +5 more
TL;DR: In this paper, the authors used the marker polyethylene glycol-400 ingested with a standard meal to assess the intestinal permeability of patients with Crohn's disease and their unaffected relatives.
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Early Presentation of Type 2 Diabetes in Mexican-American Youth
TL;DR: This diagnosis should be considered in young Hispanic patients, who might otherwise be assumed to have type 1 diabetes, and also when caring for overweight Hispanic youth with a family history of type 2 diabetes, in whom intervention may prevent or delay diabetes onset.
Journal ArticleDOI
Genetic marker associations with proliferative retinopathy in persons diagnosed with diabetes before 30 yr of age.
Karen J. Cruickshanks,Constance M. Vadheim,Scot E. Moss,Marie Paule Roth,William J. Riley,Noel K. Maclaren,Deston Langfield,Robert S. Sparkes,Ronald Klein,Jerome I. Rotter +9 more
TL;DR: The data suggest that the genetically determined immunopathic mechanisms leading to diabetes, and in linkage disequilibrium with DR4, may independently contribute to the development of proliferative retinopathy.
Journal ArticleDOI
Inherited susceptibility to insulin-dependent diabetes is associated with HLA-DR1, while DR5 is protective.
Noel K. Maclaren,William J. Riley,Nicos Skordis,Mark A. Atkinson,Rebecca Spillar,Janet H. Silverstein,Ronald Klein,Constance M. Vadheim,Jerome I. Rotter +8 more
TL;DR: It is concluded that DR1 is an additional risk DR allele for IDD to that of DR3 and DR4, and DR5 an additional protective DR allele to thatof DR2.