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Corey Raffel
Researcher at University of California, San Francisco
Publications - 133
Citations - 7780
Corey Raffel is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Medulloblastoma & Primitive neuroectodermal tumor. The author has an hindex of 44, co-authored 132 publications receiving 7257 citations. Previous affiliations of Corey Raffel include University of Minnesota & University of Rochester.
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Journal ArticleDOI
Mutations in SUFU predispose to medulloblastoma
Michael D. Taylor,Ling Liu,Corey Raffel,Chi-chung Hui,Todd G. Mainprize,Xiaoyun Zhang,Ron Agatep,Sharon Chiappa,Luzhang Gao,Anja Lowrance,Aihau Hao,Alisa M. Goldstein,Theodora Stavrou,Stephen W. Scherer,Wieslaw T. Dura,Brandon J. Wainwright,Jeremy A. Squire,James T. Rutka,David Hogg +18 more
TL;DR: It is reported that a subset of children with medulloblastoma carry germline and somatic mutations in SUFU (encoding the human suppressor of fused) of the SHH pathway, accompanied by loss of heterozygosity of the wildtype allele.
Journal Article
Sporadic Medulloblastomas Contain PTCH Mutations
Corey Raffel,Robert B. Jenkins,Lori Frederick,Deanne Hebrink,Benjamin Alderete,Daniel W. Fults,C. David James +6 more
TL;DR: Data suggest that inactivation of PTCH function is involved in the development of at least a subset of sporadic medulloblastomas, and it is interesting that all three mutations occur in exon 17 of the PTCH gene.
Journal ArticleDOI
MDR1 gene expression in brain of patients with medically intractable epilepsy.
David M. Tishler,Kenneth I. Weinberg,David R. Hinton,Nicholas M. Barbaro,Geralyn Annett,Corey Raffel,Corey Raffel +6 more
TL;DR: MDR1 expression is increased in brain of some patients with medically intractable epilepsy, suggesting that the patients’ lack of response to medication may be caused by inadequate accumulation of AED in brain.
Journal Article
Sporadic Medulloblastomas Contain Oncogenic β-Catenin Mutations
TL;DR: Data suggest that activating mutations in the β- catenin gene may be involved in the development of a subset of medulloblastomas, and that the GSK-3 β gene does not appear to be a target for inactivation in this tumor.
Journal ArticleDOI
Analysis of PTCH/SMO/SHH pathway genes in medulloblastoma.
Russell H. Zurawel,Cory Allen,Sharon Chiappa,Walter Cato,Jaclyn A. Biegel,Philip Cogen,Frederic J. de Sauvage,Corey Raffel +7 more
TL;DR: Inactivation of the PTCH tumor suppressor gene occurs in a subset of sporadic medulloblastomas, suggesting that alterations in thePTCH pathway may be important in the development of this tumor.