L
Luzhang Gao
Researcher at University of Toronto
Publications - 5
Citations - 1110
Luzhang Gao is an academic researcher from University of Toronto. The author has contributed to research in topics: Loss of heterozygosity & Exon. The author has an hindex of 4, co-authored 5 publications receiving 1057 citations.
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Journal ArticleDOI
Mutations in SUFU predispose to medulloblastoma
Michael D. Taylor,Ling Liu,Corey Raffel,Chi-chung Hui,Todd G. Mainprize,Xiaoyun Zhang,Ron Agatep,Sharon Chiappa,Luzhang Gao,Anja Lowrance,Aihau Hao,Alisa M. Goldstein,Theodora Stavrou,Stephen W. Scherer,Wieslaw T. Dura,Brandon J. Wainwright,Jeremy A. Squire,James T. Rutka,David Hogg +18 more
TL;DR: It is reported that a subset of children with medulloblastoma carry germline and somatic mutations in SUFU (encoding the human suppressor of fused) of the SHH pathway, accompanied by loss of heterozygosity of the wildtype allele.
Journal ArticleDOI
Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma
Ling Liu,David J. Dilworth,Luzhang Gao,Jose Monzon,Ann Summers,Norman J. Lassam,David W. Hogg +6 more
TL;DR: It is shown here that a subset of these kindreds possess a G→T transversion at base –34 of CDKN2A, designated G–34T, which gives rise to a novel AUG translation initiation codon that decreases translation from the wild-type AUG.
Journal Article
Patterns of CDKN2A gene loss in sequential oral epithelial dysplasias and carcinomas.
S. Ali Shahnavaz,Grace Bradley,Joseph A. Regezi,Nalin Thakker,Luzhang Gao,David Hogg,Richard C.K. Jordan +6 more
TL;DR: During oral carcinogenesis homozygous deletion of exon 1alpha of the CDKN2A gene is common but that deletion ofExon 2 and 1beta is less frequent, suggesting that the progression from oral precancer to cancer, in some cases, is more complex genetically than predicted by linear models of carcinogenesis.
Journal Article
Lack of germ-line mutations of CDK4, p16(INK4A), and p15(INK4B) in families with glioma.
Luzhang Gao,Liyang Liu,D. van Meyel,Gregory Cairncross,Peter Forsyth,David W. Kimmel,Robert B. Jenkins,Norman J. Lassam,David Hogg +8 more
TL;DR: Despite the association between the sporadic forms of high-grade glioma and abnormalities of p16(inks4A), p15(INK4B), or CDK4, it is found no evidence that germ-line mutations in the coding region of these three genes predispose to inherited glial tumors.