C
Chi-chung Hui
Researcher at University of Toronto
Publications - 142
Citations - 24258
Chi-chung Hui is an academic researcher from University of Toronto. The author has contributed to research in topics: Sonic hedgehog & Hedgehog signaling pathway. The author has an hindex of 65, co-authored 134 publications receiving 22158 citations. Previous affiliations of Chi-chung Hui include New York University & Guy's Hospital.
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Journal ArticleDOI
Angiotensin-converting enzyme 2 protects from severe acute lung failure
Yumiko Imai,Keiji Kuba,Shuan Rao,Yi Huan,Feng Guo,Bin Guan,Peng Yang,Renu Sarao,Teiji Wada,Howard Leong-Poi,Michael A. Crackower,Akiyoshi Fukamizu,Chi-chung Hui,Lutz Hein,Stefan Uhlig,Arthur S. Slutsky,Chengyu Jiang,Josef M. Penninger +17 more
TL;DR: It is reported that ACE2 and the angiotensin II type 2 receptor (AT2) protect mice from severe acute lung injury induced by acid aspiration or sepsis, pointing to a possible therapy for a syndrome affecting millions of people worldwide every year.
Journal ArticleDOI
Obesity-associated variants within FTO form long-range functional connections with IRX3
Scott Smemo,Juan J. Tena,Kyoung-Han Kim,Eric R. Gamazon,Noboru J. Sakabe,Carlos Gómez-Marín,Ivy Aneas,Flavia L. Credidio,Débora R. Sobreira,Nora F. Wasserman,Ju Hee Lee,Vijitha Puviindran,Davis Tam,Michael Shen,Joe Eun Son,Niki Alizadeh Vakili,Hoon Ki Sung,Silvia Naranjo,Rafael D. Acemel,Miguel Manzanares,Andras Nagy,Nancy J. Cox,Chi-chung Hui,José Luis Gómez-Skarmeta,Marcelo A. Nobrega +24 more
TL;DR: It is shown that the obesity-associated noncoding sequences within FTO are functionally connected, at megabase distances, with the homeobox gene IRX3, and long-range enhancers within this region recapitulate aspects of IRx3 expression, suggesting that the Obesity-associated interval belongs to the regulatory landscape ofIRX3.
Journal ArticleDOI
FTO Obesity Variant Circuitry and Adipocyte Browning in Humans
Melina Claussnitzer,Simon N. Dankel,Kyoung-Han Kim,Gerald Quon,Wouter Meuleman,Christine Haugen,Viktoria Glunk,Isabel S. Sousa,Jacqueline L. Beaudry,Vijitha Puviindran,Nezar Abdennur,Jannel Liu,Per-Arne Svensson,Yi-Hsiang Hsu,Daniel J. Drucker,Gunnar Mellgren,Chi-chung Hui,Hans Hauner,Manolis Kellis,Manolis Kellis +19 more
TL;DR: The data indicate that the FTO allele associated with obesity represses mitochondrial thermogenesis in adipocyte precursor cells in a tissue-autonomous manner, and points to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-ob obesity effects.
Journal ArticleDOI
Notch1 functions as a tumor suppressor in mouse skin.
Michael Nicolas,Anita Wolfer,Kenneth Raj,J. Alain Kummer,Pleasantine Mill,Mascha van Noort,Chi-chung Hui,Hans Clevers,G. Paolo Dotto,Freddy Radtke +9 more
TL;DR: The results indicate that Notch1 functions as a tumor-suppressor gene in mammalian skin and can inhibit β-catenin-mediated signaling.
Journal ArticleDOI
Hedgehog signaling in development and cancer.
Jin Jiang,Chi-chung Hui +1 more
TL;DR: The current understanding of the molecular and cellular basis of Hh morphogen gradient formation and signal transduction, and the multifaceted roles of HH signaling in development and tumorigenesis are reviewed.