T
Todd G. Mainprize
Researcher at Sunnybrook Health Sciences Centre
Publications - 72
Citations - 4211
Todd G. Mainprize is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Medulloblastoma & Radiosurgery. The author has an hindex of 26, co-authored 72 publications receiving 3602 citations. Previous affiliations of Todd G. Mainprize include University of Toronto.
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Journal ArticleDOI
Mutations in SUFU predispose to medulloblastoma
Michael D. Taylor,Ling Liu,Corey Raffel,Chi-chung Hui,Todd G. Mainprize,Xiaoyun Zhang,Ron Agatep,Sharon Chiappa,Luzhang Gao,Anja Lowrance,Aihau Hao,Alisa M. Goldstein,Theodora Stavrou,Stephen W. Scherer,Wieslaw T. Dura,Brandon J. Wainwright,Jeremy A. Squire,James T. Rutka,David Hogg +18 more
TL;DR: It is reported that a subset of children with medulloblastoma carry germline and somatic mutations in SUFU (encoding the human suppressor of fused) of the SHH pathway, accompanied by loss of heterozygosity of the wildtype allele.
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A systematic review of the effects of resident duty hour restrictions in surgery: impact on resident wellness, training, and patient outcomes.
Najma Ahmed,Katharine S. Devitt,Itay Keshet,Jonathan Spicer,Kevin Imrie,Liane S. Feldman,Jonathan Cools-Lartigue,Ahmed Kayssi,Nir Lipsman,Maryam Elmi,Abhaya V. Kulkarni,Chris Parshuram,Todd G. Mainprize,Richard Warren,Paola Fata,M. Sean Gorman,Stan Feinberg,James T. Rutka +17 more
TL;DR: Recent RDH changes are not consistently associated with improvements in resident well-being, and have negative impacts on patient outcomes and performance on certification examinations.
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Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study
Todd G. Mainprize,Nir Lipsman,Nir Lipsman,Yuexi Huang,Ying Meng,Ying Meng,Allison Bethune,Sarah Ironside,Chinthaka Heyn,Ryan Alkins,Maureen Trudeau,Arjun Sahgal,Arjun Sahgal,James Perry,James Perry,Kullervo Hynynen,Kullervo Hynynen +16 more
TL;DR: In this article, the MRgFUS with intravenously injected microbubbles can temporarily and repeatedly disrupt the blood-brain barrier (BBB) in a targeted fashion, without open surgery.
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First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
Agessandro Abrahao,Agessandro Abrahao,Ying Meng,Ying Meng,Maheleth Llinas,Maheleth Llinas,Yuexi Huang,Clement Hamani,Clement Hamani,Todd G. Mainprize,Isabelle Aubert,Isabelle Aubert,Chinthaka Heyn,Sandra E. Black,Kullervo Hynynen,Nir Lipsman,Nir Lipsman,Lorne Zinman +17 more
TL;DR: It is demonstrated that non-invasive BBB permeabilization over the motor cortex using MRgFUS is safe, feasible, and reversible in ALS subjects, and suggested that the procedure could in the future be used to increase drug delivery in ALS patients.
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Intracranial Pressure Monitoring in Severe Traumatic Brain Injury: Results from the American College of Surgeons Trauma Quality Improvement Program
Aziz S. Alali,Robert A. Fowler,Todd G. Mainprize,Damon C. Scales,Alexander Kiss,Charles de Mestral,Joel G. Ray,Avery B. Nathens +7 more
TL;DR: In this observational study, intracranial pressure monitoring utilization was associated with lower mortality, however, variability in ICP monitoring rates contributed only modestly to variability in institutional mortality rates.