Corey W. Liu

TL;DR: NMR spectroscopy is used to characterize the conformational dynamics of the transmembrane core of the β(2)-adrenergic receptor (β(2)AR), a prototypical GPCR, and shows that for β( 2)AR, unlike rhodopsin, an agonist alone does not stabilize a fully active conformation.

TL;DR: Rapamycin's ability to bind to FRB, and by extension to mTOR, in the absence of FKBP is of little consequence under physiological conditions, and protein-protein interactions at the FK BP12-FRB interface play a role in the stability of the ternary complex.

TL;DR: NMR spectroscopy is used to demonstrate conformational coupling between the ECS and the orthosteric binding site, showing that drugs targeting this diverse surface could function as allosteric modulators with high subtype selectivity.

TL;DR: In this paper, NMR spectroscopy was used to characterize the conformational dynamics of the transmembrane core of the b2-adrenergic receptor (b2AR), a prototypical GPCR.

TL;DR: In this paper, a review of P NMR studies of soil has been presented, including pre-and post-extraction treatments, the physical state of the soil sample at the time of extraction, extraction length, extraction ratio, soil/extractant ratio, P recovery, P in residues, methods to concentrate extracts, redissolving samples for ³¹P NMR experiments, and the use of the internal standard methylene diphosphonic acid.